| 黄芩苷体内抗流感病毒作用 |
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| 引用本文： | 初正云,初明,滕宇.黄芩苷体内抗流感病毒作用[J].中国中药杂志,2007,32(22):2413-2415. |
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| 作者姓名： | 初正云 初明 滕宇 |
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| 作者单位： | 1. 辽宁中医药大学,药学院,辽宁,大连,116600
2. 北京大学,医学部,北京,100083 |
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| 摘 要： | 目的：研究黄芩苷体内抗流感病毒(influenza virus,IV)作用。方法：采用体内实验方法,对小鼠先预防给药(2 d)后感染流感病毒(A/FM/1/47)或先感染流感病毒(1 d)后治疗给药的方法观察黄芩苷的抗流感病毒作用。结果：黄芩苷可明显延长流感病毒感染小鼠的存活时间(P<0.01)；对小鼠肺内的流感病毒有一定的清除作用,能降低肺内流感病毒的血凝滴度和感染力；减轻小鼠肺内的炎性病变。结论：黄芩苷具有明显的抗流感病毒作用。
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| 关 键 词： | 黄芩苷 流感病毒 肺指数 |
| 文章编号： | 1001-5302（2007）22-2413-03 |
| 收稿时间： | 2007-04-20 |
| 修稿时间： | 2007年4月20日 |
Effect of baicalin on in vivo anti-virus |
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| CHU Zheng-yun; CHU Ming; TENG Yu.Effect of baicalin on in vivo anti-virus[J].China Journal of Chinese Materia Medica,2007,32(22):2413-2415. |
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| Authors: | CHU Zheng-yun; CHU Ming; TENG Yu |
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| Affiliation: | 1. Pharmacy department, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China ; 2. Department of lmmunology, School of Basic Medicine, Beijing University, Bering 100083, China |
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| Abstract: | Objective: This study is about the in vivo antivirus effect of baicalin.Method: Adopting in vivo experiment,we administered one group of mice 2 days before infected with influenza virus(A/FM/1/47),while administer the other group with baicalin one day after infected,to observe the effect of baicalin in protecting and curing mice against influenza virus.Result: Baicalin can obviously prolong the survival time of mice infected with influenza virus(A/FM/1/47)(P<0.01),eliminate the influenza virus in lung,reduce the hemagglutination tite and infectivity in pulmo,and reverse mice's pneumonic pathological changes.Conclusion: Baicalin can obviously counteract influenza virus. |
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| Keywords: | baicalin influenza virus pulmo index |
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