| 桑叶中糖苷酶抑制活性组分的筛选 |
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| 引用本文： | 原爱红,马骏,蒋晓峰,李素.桑叶中糖苷酶抑制活性组分的筛选[J].中国中药杂志,2006,31(3):223-227. |
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| 作者姓名： | 原爱红 马骏 蒋晓峰 李素 |
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| 作者单位： | 同济大学,附属同济医院,上海,200065 |
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| 摘 要： | 目的:筛选桑叶中具有糖苷酶抑制活性的组分。方法:采用柱色谱法将桑叶水提物进行分离,并利用体外糖苷酶抑制模型对活性部位进行跟踪研究,进一步通过小鼠体内糖耐量实验验证其效果。结果:体外和体内实验结果表明桑叶提取物中生物碱、黄酮、多糖等部位均有糖苷酶抑制活性,其中生物碱组分活性最强。结论:桑叶的降糖作用与各组分的糖苷酶抑制活性有关。
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| 关 键 词： | 桑叶 生物碱 糖尿病 糖苷酶 |
| 文章编号： | 1001-5302（2006）03-0223-05 |
| 收稿时间： | 2004-04-12 |
| 修稿时间： | 2004-04-12 |
Screening of glucosidase inhibitors from various fractions of mulberry leaves |
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| YUAN Ai-hong;MA Jun;JIANG Xiao-feng;LI Su.Screening of glucosidase inhibitors from various fractions of mulberry leaves[J].China Journal of Chinese Materia Medica,2006,31(3):223-227. |
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| Authors: | YUAN Ai-hong;MA Jun;JIANG Xiao-feng;LI Su |
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| Affiliation: | Department of Nephrology, Tongji Hospital of Tongji University, Shanghai 200065, China |
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| Abstract: | Objective: To search for glucosidase inhibitors of various fractions extracted from mulberry leaves.Method: The constituents of mulberry leaves water fraction were prepared by the process of boiling,condensing,precipitating,exchanging with resins and rinsing.In vitro glucosidase inhibitory activities were examined by photometric bioassay derived from rats.To investigate in vivo effect of lowering blood glucose,the mouse blood glucose level was assayed by glucose tolerance experiments.Result: The glucosidase inhibitory activities were found in all the constituents of alkaloids,flavones and amyloses,the alkaloid constituent being the strongest.Conclusion: The effect of reducing blood glucose of mulberry leaves is related to the inhibitory activities against glucosidase of different constituents. |
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| Keywords: | mulberry leaves alkaloid diabetes mellitus glucosidase |
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