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水飞蓟素滴丸的溶出度研究
引用本文:孙霞,邱明丰,李绍顺,王建新,沈琦,贾伟.水飞蓟素滴丸的溶出度研究[J].中国中药杂志,2005,30(4):263-265.
作者姓名:孙霞  邱明丰  李绍顺  王建新  沈琦  贾伟
作者单位:1. 上海交通大学,上海,200030
2. 上海市中药研究所,上海,200127
摘    要:目的:考察水飞蓟素滴丸的溶出度,并与市售水飞蓟素制剂进行比较。方法:以紫外分光光度法测定样品中水飞蓟素的含量,研究了水飞蓟素滴丸的溶出条件,并在此基础上测定比较了水飞蓟素滴丸、市售益肝灵片(薄膜衣,糖衣)及利加隆胶囊的溶出度。结果:水飞蓟素滴丸、益肝灵片(薄膜衣)、益肝灵片(糖衣)和利加隆胶囊的T50Td分别为6.78,9.85 min;51.01,73.78 min;74 35,86.97 min;53.10,72.65 min。结论:滴丸的溶出明显优于市售片剂和胶囊。

关 键 词:水飞蓟素滴丸  溶出度  紫外分光光度法
文章编号:1001-5302(2005)04-0263-03
收稿时间:2004/6/15 0:00:00

Studies on dissolution rate in vitro of silymarin dropping pill
SUN Xia;QIU Ming-feng;LI Shao-shun;WANG Jian-xin;SHEN Qi;JIA Wei.Studies on dissolution rate in vitro of silymarin dropping pill[J].China Journal of Chinese Materia Medica,2005,30(4):263-265.
Authors:SUN Xia;QIU Ming-feng;LI Shao-shun;WANG Jian-xin;SHEN Qi;JIA Wei
Affiliation:Shanghai Jiao Tong University, Shanghai 200030, China.
Abstract:Objective: To test the dissolution rate of silymarin dropping pill as well as to be compared with other three commercial products of the silymarin. Method: By UV spectrophotometry, we studied the dissolution conditions of silymarin dropping pill and compared its dissolution rate with Yiganling tablets (film-coating, sugar-coating) and Legalon capsule which are available in the market. Result: The dissolution parameters T50 and Td of silymarin dropping pill, Yiganling tablet (film-coating), Yiganling tablet (sugar-coating) and Legalon capsule are 6.78, 9.85 min, 51.01, 73.78 min, 74.35, 86.97 min and 53.10 , 72.65 min. Conclusion: The dissolution rate of silymarin dropping pill is superior to that of two kinds of Yiganling tablets and Legalon capsule.
Keywords:silymarin dropping pill  dissolution rate  UV spectrophotometry
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