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长春花抗癌成分长春新碱研究的进展
引用本文:卢懿,侯世祥,陈彤.长春花抗癌成分长春新碱研究的进展[J].中国中药杂志,2003,28(11):1006-1009.
作者姓名:卢懿  侯世祥  陈彤
作者单位:四川大学,药学院,四川,成都,610041
摘    要:长春新碱是从抗癌中药长春花叶中提出的二聚吲哚类生物碱 ,临床上用于治疗急性淋巴细胞白血病、何杰金及非何杰金淋巴瘤有确切疗效 ,但由于具有较大的神经系统毒性和局部刺激性 ,限制了其在临床上的应用。本文在简述其理化、药理、药动学特性基础上 ,综述了为解决长春新碱副作用 ,临床上主要采用联合用药方式的研究进展 ,及制剂学上 ,采用与抗体结合、脂质体包裹以及控释膜等制剂新技术、新方法的研究进展。

关 键 词:长春新碱  性质  新型给药系统  临床
文章编号:1001-5302(2003)11-1006-04
收稿时间:2002/11/20 0:00:00
修稿时间:2002年11月20

Advances in the Study of Vincristine An Anticancer Ingredient from Gatharanthus Roseus
LU Yi;HOU Shi-xiang;CHEN Tong.Advances in the Study of Vincristine An Anticancer Ingredient from Gatharanthus Roseus[J].China Journal of Chinese Materia Medica,2003,28(11):1006-1009.
Authors:LU Yi;HOU Shi-xiang;CHEN Tong
Affiliation:College of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China. toLuYi@eyou.com
Abstract:Vincristine is a dimer-indo-alkaloid w hich is extracted from the lea ves of Gatharanthus roseus.It is effective to treat acute lymphocytic cell leuk emia,Hodgkin disease and non- Hodgkin disease clinically.But the severe sid e effects, such as neurotoxic and tissue damage, limit its application. In this paper, we summarize physical, chemical,pharmacological and pharmacokinetical pr operties of VCR and advances in decreasing its side effects. In clinic, associa tion with other medication is adopted. In pharmaceutics,people adopt some new m ethods and technology such as conjugation with the antibody, encapsulation in l iposomes or controlled release films.
Keywords:vincristine  properties  new drug del ivery system  clinic
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