| 决明子蛋白质和蒽醌苷对高脂血症大鼠血脂的影响 |
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| 引用本文： | 李续娥,郭宝江.决明子蛋白质和蒽醌苷对高脂血症大鼠血脂的影响[J].中国中药杂志,2002,27(5):374-376. |
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| 作者姓名： | 李续娥 郭宝江 |
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| 作者单位： | 华南师范大学,生物技术研究所,广东,广州,510631 |
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| 基金项目： | 陕西省自然科学基金资助项目 (99SM74) |
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| 摘 要： | 目的 :考察决明子蛋白质和蒽醌苷对高脂血症大鼠血脂的影响。方法 :采用灌胃脂肪乳剂建立大鼠的高脂血症模型。用酶比色法测定决明子蛋白质和蒽醌苷的不同剂量、以及两者小剂量合用后 ,对高脂血症大鼠的血清总胆固醇 (TC)、甘油三酯 (TG)、低密度脂蛋白 (LDL-C)和高密度脂蛋白 (HDL-C)的影响。结果 :决明子蛋白质大剂量 (1mg·kg-1·d-1)、蒽醌苷大剂量 (20mg·kg-1·d-1)以及两者的小剂量 (蛋白质 0.25mg·kg-1·d-1,蒽醌苷 5mg·kg-1·d-1)合用 ,均可使高脂血症大鼠的TC ,TG和LDL C显著降低 (P<0.05 ,P<0.01)。结论 :试验结果表明 ,决明子蛋白质、蒽醌苷皆可降低高脂血症大鼠的TC ,TG和LDL-C。
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| 关 键 词： | 决明子 蛋白质 蒽醌苷 血脂 |
| 文章编号： | 1001-5302(2002)05-0374-03 |
| 收稿时间： | 2001/3/23 0:00:00 |
| 修稿时间： | 2001年3月23日 |
Effect of Protein and Anthraquinone Glucosides from Cassia Seed on Serum Lipid of Hyperlipidemia Rats |
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| LI Xu e;GUO Bao jiang.Effect of Protein and Anthraquinone Glucosides from Cassia Seed on Serum Lipid of Hyperlipidemia Rats[J].China Journal of Chinese Materia Medica,2002,27(5):374-376. |
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| Authors: | LI Xu e;GUO Bao jiang |
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| Affiliation: | Institute of Biological Technology, South China Normal University, Guangzhou 510631, Guangdong, China. lixue@scnu.edu.cn |
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| Abstract: | Objective: To study the effect of protein and anthraquinone glucosides from cassia seed on serum lipid of hyperlipidemia rats.Method: The rat hyperlipidemia model was set up by ig lipid emulsion. The effects of the protein 0.25 and 1 mg·kg-1 ·d-1 , the anthraquinone glucosides 5 and 20 mg·kg-1 ·d-1 , and the protein 0.25 mg·kg-1 ·d-1 plus the anthracene glucosides 5 mg·kg-1 ·d-1 on total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL C) and high density lipoprotein (HDL C) in serum of the rats were determined. Result: The protein 1 mg·kg-1 ·d -1 , the anthraquinone glucosides 20 mg·kg-1 ·d -1 reduced the raised TC, TG, LDL C of hyperlipidemia rats ( P <0.05). The above indexes could also be reduced by the protein 0.25 mg·kg-1 ·d -1 plus the anthraquinone glucosides 5 mg·kg-1 ·d-1 (P<0.05, P<0.01). Conclusion: Protein and anthraquinone glucosides from cassia seed can lower TC, TG, LDL C of hyperlipidemia rats. |
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| Keywords: | Cassia Seed protein anthraquinone glucosides serum lipid |
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