| 漏芦多糖对小鼠激发态免疫功能的影响及其可能机制 |
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| 引用本文： | 李发胜,杨光,咸丰,刘辉,.漏芦多糖对小鼠激发态免疫功能的影响及其可能机制[J].中国中药杂志,2007,32(5):433-435. |
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| 作者姓名： | 李发胜 杨光 咸丰 刘辉 |
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| 作者单位： | 1. 大连医科大学,检验医学院,辽宁,大连,116027
2. 大连市沈阳军区第一疗养院,辽宁,大连,116013 |
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| 摘 要： | 目的：探讨漏芦多糖对小鼠免疫反应的影响及作用机制。方法：分别用绵羊红细胞(SRBC)和卵清蛋白为抗原给小鼠注射后,将漏芦多糖分为3个剂量(50,100,200 mg·kg-1·d-1)灌服小鼠7 d,加强免疫后,检测相应抗体生成水平和血清中白细胞介素-2(IL-2),γ-干扰素(IFN-γ)生成水平。结果：中剂量给药组SRBC抗体生成水平和卵清抗体生成水平,IL-2,IFN-γ激发水平均显著高于对照组(P<0.05)。结论：漏芦多糖对正常小鼠机体免疫有增强作用。
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| 关 键 词： | 漏芦多糖 免疫 IFN-γ |
| 文章编号： | 1001-5302（2007）05-0433-03 |
| 收稿时间： | 2005-07-10 |
| 修稿时间： | 2005-07-10 |
Effects of Rhaponticum uniforum polysaccharide on immune response of mice after antigen stimulation and their possible mechanisms |
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| LI Fa-sheng; YANG Guang; XIAN Feng; LIU Hui.Effects of Rhaponticum uniforum polysaccharide on immune response of mice after antigen stimulation and their possible mechanisms[J].China Journal of Chinese Materia Medica,2007,32(5):433-435. |
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| Authors: | LI Fa-sheng; YANG Guang; XIAN Feng; LIU Hui |
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| Affiliation: | College of Clinical Laboratory, Dalian Medical University, Dalian 116027, China. |
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| Abstract: | OBJECTIVE: To study the effects of Rhaponticum uniforum polysaccharide on immune function in normal mice and the underlying mechanism. METHOD: SRBC and ovalbumin were employed as antigens to be injected to mice, respectively. Three doses of R. uniforum polysaccharide (50, 100, 200 mg x kg(-1) x d(-1)) were given orally for seven days. After the secondary immunization, the level of corresponding antibody and the concentration of serum IL-2, IFN-gamma were determined. RESULT: The levels of antibodies (anti-SRBC and anti-ovalbumin) and cytokines (IL-2 and IFN-gamma) in median dose group of R. uniforum polysaccharide were all significantly higher than those in control groups (P <0.05). CONCLUSION: R. uniforum polysaccharide could enhance the immune function in normal mice. |
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| Keywords: | IL-2 |
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