| 藏药五脉绿绒蒿中非生物碱成分 |
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| 引用本文： | 尚小雅,李冲,张承忠,杨永春,石建功.藏药五脉绿绒蒿中非生物碱成分[J].中国中药杂志,2006,31(6):468-471. |
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| 作者姓名： | 尚小雅 李冲 张承忠 杨永春 石建功 |
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| 作者单位： | 1. 中国医学科学院,中国协和医科大学,药物研究所,北京,100050
2. 兰州大学,药学院,甘肃,兰州,730000 |
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| 基金项目： | 北京市科委248生物技术项目 |
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| 摘 要： | 目的:研究藏药五脉绿绒蒿Meconopsis quintuplinervia的化学成分。方法:应用色谱技术分离纯化,用波谱学方法确定化合物结构。结果:从乙醇提取物中分离得到12个化合物,分别鉴定为:槲皮素-3-O-β-D-葡萄糖苷(Ⅰ),槲皮素-3-O-β-D-半乳糖(1→6)]-β-D-葡萄糖苷(Ⅱ),山柰素-3-O-β-D-葡萄糖(1→2)]-β-D-葡萄糖苷(Ⅲ),异鼠李黄素-3-O-β-D-半乳糖苷(1→6)]-β-D-葡萄糖(Ⅳ),咖啡酸(Ⅴ),原儿茶酸(Ⅵ),对羟基肉桂酸(Ⅶ),2-(3,4-二羟苯基)-乙醇β-D-吡喃葡萄糖苷(Ⅷ),对羟基苯甲酸β-D-吡喃葡萄糖酯苷(Ⅸ),肉桂酸4-O-β-D-吡喃葡萄糖苷(Ⅹ),5,7-二羟基色原酮(Ⅺ),胡萝卜苷(Ⅻ)。结论:除Ⅵ和Ⅻ外,其余10个化合物均为首次从该属植物中发现。
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| 关 键 词： | 藏药 罂粟科 五脉绿绒蒿 黄酮苷 芳香酸 芳香吡喃葡萄糖苷 |
| 文章编号： | 1001-5302（2006）06-0468-04 |
| 收稿时间： | 2005-09-25 |
| 修稿时间： | 2005-09-25 |
Non-alkaloid constituents from a Tibetan medicine Meconopsis quintuplinervia |
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| SHANG Xiao-ya,;LI Chong,;ZHANG Cheng-zhong,;YANG Yongchun,;SHI Jian-gong.Non-alkaloid constituents from a Tibetan medicine Meconopsis quintuplinervia[J].China Journal of Chinese Materia Medica,2006,31(6):468-471. |
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| Authors: | SHANG Xiao-ya ;LI Chong ;ZHANG Cheng-zhong ;YANG Yongchun ;SHI Jian-gong |
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| Affiliation: | 1 Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, 2. School of Pharmaceutical Sciences, Lanzhou University,Lanzhou 730000, China |
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| Abstract: | OBJECTIVE: To study the chemical constituents of a Tibetan medicine Meconopsis quintuplinervia. METHOD: Column chromatographic techniques were applied to isolate constituents. A combination of IR, MS and NMR spectroscopy was used to identify structures of constituents. RESULT: Twelve compounds were isolated from the ethanolic extract and their structures were elucidated as quercetin 3-O-beta-D-glucopyranoside (I), quercetin 3-O-beta-D-galactopyranosyl-(1-->6)-glucopyranoside (II), kaempferol 3-O-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranoside (III), isorhamnetin 3-0-beta-D-galactopyranosyl-(1-->6)-beta-D-glucopyranoside (IV), caffeic acid (V), protocatechuic acid (VI), p-hydroxycinnamic (VII), 2-(3,4-dihydroxyphenyl )-ethyl-O-beta-D-glucopyranoside (VIII), p-hydroxybenzoyl-beta-D-glucopyranoside (IX), 4-O-beta-D-glucopyranosyl-(Z)-p-coumaric acid (X), 5, 7-dihydroxy-4H-4-chromenone (XI), daucosterol (XII). CONCLUSION: Ten compounds were isolated from this genus for the first time except for XI and XII. |
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| Keywords: | Tibetan medicine Papaveraceae Meconopsis quintuplinervia flavonol glycosides aromatic acid aromatic glucopyranoside |
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