|
|||||
|
|
| 均匀设计法优选桂枝茯苓丸方药的半仿生提取工艺条件 | |
| 引用本文： | 李芳,张兆旺,孙秀梅,王卫锋,马梅芳.均匀设计法优选桂枝茯苓丸方药的半仿生提取工艺条件[J].中国中药杂志,2010,35(16):2151-2156. |
| 作者姓名： | 李芳 张兆旺 孙秀梅 王卫锋 马梅芳 |
| 作者单位： | 1. 陕西省中医药研究院,陕西,西安,710003 2. 山东中医药大学,山东,济南,250014 3. 枣庄市药品检验所,山东,枣庄,277102 |
| 摘 要： | 目的:优选桂枝茯苓丸方药的半仿生提取工艺条件。方法:将方中含挥发性成分中药超临界萃取后的药渣与方中茯苓混合,以芍药苷、肉桂酸、苦杏仁苷、茯苓酸、总多糖、干浸膏为指标,采用均匀设计优选其半仿生提取法(简称SBE法)的工艺条件。结果:优化条件为3煎用水pH依次为4.98,7.35,8.00,煎煮总时间为4.99 h。结论:结合生产实际,确定其SBE法工艺条件为3煎用水的pH依次为5.0,7.5,8.0;煎煮时间依次为2.0,1.5,1.5 h。 |
| 关 键 词： | 桂枝茯苓丸方药 半仿生提取 均匀设计 工艺条件 |
| 收稿时间： | 2/1/2010 12:00:00 AM |
Optimization of extraction conditions for semi-bionic extraction of Guizhi Fuling pill decoction by uniform design |
|
| LI Fang,ZHANG Zhaowang,SUN Xiumei,WANG Weifeng and MA Meifang.Optimization of extraction conditions for semi-bionic extraction of Guizhi Fuling pill decoction by uniform design[J].China Journal of Chinese Materia Medica,2010,35(16):2151-2156. | |
| Authors: | LI Fang ZHANG Zhaowang SUN Xiumei WANG Weifeng and MA Meifang |
| Affiliation: | Shanxi Provincial Academy of Traditional Chinese Medicine, Xi'an 710003, China;Shandong University of Traditional Chinese Medicine, Jinan 250014, China;Shandong University of Traditional Chinese Medicine, Jinan 250014, China;Shanxi Provincial Academy of Traditional Chinese Medicine, Xi'an 710003, China;Zao Zhuang Institute of Drug Control, Zaozhuang 277102, China |
| Abstract: | Objective : To optimize the extraction conditions for semi-bionic extraction of Guizhi Fuling pill decoction. Method : The best extraction condition of the semi-bionic extraction for Guizhi Fuling pill decoction was optimized by uniform design was optimized with paeoniflorin, cinnamic acid, laetrile, pachymic acid, total polysaccharose and dry extract as the indexes. Result : The optimized extraction condition is that extracting for 3 times with solvent pH values of 4.98, 7.35 and 8.00, respectively, and the total extracting time was 4.99 h. Conclusion : In consideration of manufacturing fact, the pH value of thrice extractions is set at 5.0, 7.5, 8.0 respectively, and the extracting time is 2.0, 1.5, 1.5 h in turn. |
| Keywords: | Guizhi Fuling pills decoction semi-bionic extraction uniform design extraction condition |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
