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| 大承气汤煎煮过程去厚朴、枳实药渣与否其汤剂中蒽醌类成分含量的研究 | |
| 引用本文： | 王跃生,邓杰华,魏惠珍,饶毅,申峰云,金浩鑫.大承气汤煎煮过程去厚朴、枳实药渣与否其汤剂中蒽醌类成分含量的研究[J].中国中药杂志,2013,38(5):694-697. |
| 作者姓名： | 王跃生 邓杰华 魏惠珍 饶毅 申峰云 金浩鑫 |
| 作者单位： | 1. 中药固体制剂制造技术国家工程研究中心,江西南昌330006 ;中国中医科学院中药研究所,北京100700 2. 江西中医学院,江西南昌,330006 3. 中药固体制剂制造技术国家工程研究中心,江西南昌,330006 |
| 基金项目： | 国家重点基础研究发展计划(973)项目(2010CB530602) |
| 摘 要： | 目的:《伤寒论》中大承气汤的煎煮古法“以水一斗,先煮二物(厚朴、枳实),取五升,去滓,纳大黄,更煮取二升,去滓,纳芒硝,更上微火一两沸”,其中厚朴、枳实先煎后需去渣,该文旨在研究蒽醌类成分的含量,以考察去厚朴、枳实二物药渣的科学性.方法:采用传统煎煮方法煎煮大承气汤,A汤剂(原法)去厚朴、枳实药渣,B汤剂不去厚朴、枳实药渣,采用HPLC测定2份汤剂及药渣中大黄结合蒽醌、游离蒽醌的含量.结果:A汤剂中结合蒽醌、游离蒽醌均较B汤剂含量高,A药渣总蒽醌含量低于B药渣.结论:大承气汤古法煎煮方式去厚朴、枳实药渣的科学性,就在于提高了有效成分的溶出率,为其药效物质基础提供了理论依据. |
| 关 键 词： | 大承气汤 药渣 结合蒽醌 游离蒽醌 总蒽醌 含量测定 |
| 收稿时间： | 2012/9/25 0:00:00 |
Study on determination of anthraquinones in Dachengqi Tang residues of Magnolia officinalis and Citrus aurantium removed in decoction process |
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| WANG Yue-sheng,DENG Jie-hu,WEI Hui-zhen,RAO Yi,SHEN Feng-yun and JIN Hao-xin.Study on determination of anthraquinones in Dachengqi Tang residues of Magnolia officinalis and Citrus aurantium removed in decoction process[J].China Journal of Chinese Materia Medica,2013,38(5):694-697. | |
| Authors: | WANG Yue-sheng DENG Jie-hu WEI Hui-zhen RAO Yi SHEN Feng-yun and JIN Hao-xin |
| Affiliation: | National Pharmaceutical Engineering Center for Solid Preparation in Traditional Chinese Medicine, Nanchang 330006, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China;National Pharmaceutical Engineering Center for Solid Preparation in Traditional Chinese Medicine, Nanchang 330006, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China;National Pharmaceutical Engineering Center for Solid Preparation in Traditional Chinese Medicine, Nanchang 330006, China |
| Abstract: | Objective: The traditional decoction method of Dachengqi Tang is that "First boiling Magnolia officinalis and Citrus aurantium with a pipeful of water, taking out five litres from the decoction, removing residues, adding rheum officinale, boiling again, taking out two litres from it, removing residues, adding mirabilite, boiling it with low fire". According to it, residues of M. officinalis and C. aurantium should be removed after decocting.This essay aims to study the content of anthraquinones, in order to proof whether the removal of residues of M. officinalis and C. aurantium is scientific. Method: The traditional method was adopted to prepare Dachengqi Tang.Decoction A (original method) was obtained by removing residues of M. officinalis and C. aurantium, whereas decoction B was obtained without removing residues of M. officinalis and C. aurantium.The content of anthraquinones of both methods was determined with HPLC. Result: The content of both combined and free anthraquinones in decoction A was higher than that of decoction B.The content of total anthraquinones in residues of decoction A was lower than that of residue B. Conclusion: The traditional decoction method of removing residues of M. officinalis and C. aurantium from Dachengqi Tang is scientific, because it improves the dissolution rate of effective ingredients, which provides a theoretical basis for effective substances of the drug. |
| Keywords: | Dachengqi Tang residue combined anthraquinones free anthraquinones total anthraquinones determination of content |
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