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| 平肝潜阳方治疗早、中期原发性高血压病患者的临床疗效研究 | |
| 引用本文： | 钟广伟,罗艳红,相玲丽,谢勇,谢启应,李云辉,张臣.平肝潜阳方治疗早、中期原发性高血压病患者的临床疗效研究[J].中国中药杂志,2010,35(6):776-781. |
| 作者姓名： | 钟广伟 罗艳红 相玲丽 谢勇 谢启应 李云辉 张臣 |
| 作者单位： | 1. 中南大学湘雅医院中西医结合研究所,湖南长沙,410008 2. 郴州市第一人民医院心血管内科,湖南郴州,423000 3. 中南大学高血压病研究所,湖南长沙,410008 4. 湖南省第二人民医院心血管内科,湖南长沙,410006 |
| 基金项目： | 国家自然科学基金项目(30500644) |
| 摘 要： | 目的:观察平肝潜阳方对早、中期原发性高血压病患者(肝阳上亢证)的降压效果,并探讨其治疗高血压病的疗效机制。方法:采用分层随机设计的方法将348例符合纳入标准的患者分为治疗组和对照组各174例,治疗12周。观察2组治疗前后的相关症状积分、24 h动态血压(ABMP)、心率、生活质量量表评分、血脂指标改善,评价中药治疗高血压病的临床疗效,同时两组各随机抽取40例检测治疗前后血清血管紧张素Ⅱ(AngⅡ)、超敏C反应蛋白(Hs-CRP)、降钙素基因相关肽(CGRP)水平。结果:治疗后,治疗组可显著降低血压变异性和夜间血压下降率,且夜间血压下降率优于对照组(P0.05),血压变异性和总有效率也与对照组比较,无差异显著性;治疗组在改善眩晕、腰膝酸软、心烦、口干口苦、提高生活质量、降低心率、总胆固醇(TC)、甘油三脂(TG)和高密度脂蛋白(HDL-C)方面明显优于对照组(P0.05)。两组治疗后血清AngⅡ和Hs-CRP水平下降,而血清CGRP水平上升,与治疗前比较差异有显著性(P0.01);两组治疗后比较,无显著性差异。结论:平肝潜阳方对早、中期原发性高血压病患者具有较好的降压疗效,能够改善临床症状、提高生活质量、调节血脂代谢,其作用机制可能与减轻炎症反应及抑制肾素-血管紧张素-醛固酮系统(RAAS)活性有关。 |
| 关 键 词： | 高血压病 平肝潜阳方 早、中期 临床研究 |
| 收稿时间： | 2009/10/22 0:00:00 |
Clinical efficacy study on calming liver and restraining Yang formulain treating patients with mild or moderate degree of essential hypertension |
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| ZHONG Guangwei,LUO Yanhong,XIANG Lingli,XIE Yong,XIE Qiying,LI Yunhui and ZHANG Cheng.Clinical efficacy study on calming liver and restraining Yang formulain treating patients with mild or moderate degree of essential hypertension[J].China Journal of Chinese Materia Medica,2010,35(6):776-781. | |
| Authors: | ZHONG Guangwei LUO Yanhong XIANG Lingli XIE Yong XIE Qiying LI Yunhui and ZHANG Cheng |
| Affiliation: | Institute of Integrated Chinese Traditional and Western Medicine, Xiangya Hospital,Central South University, Changsha 410008, China;Institute of Integrated Chinese Traditional and Western Medicine, Xiangya Hospital,Central South University, Changsha 410008, China;Institute of Integrated Chinese Traditional and Western Medicine, Xiangya Hospital,Central South University, Changsha 410008, China;Department of Cardiology, First People's Hospital of Chenzhou, Chenzhou 423000, China;Institute of hypertensive disease, Xiangya Hospital, Central South University, Changsha 410008, China;Institute of Integrated Chinese Traditional and Western Medicine, Xiangya Hospital,Central South University, Changsha 410008, China;Department of Cardiopathy, Second Hospital of People in Hunan Province, Changsha 410007, China |
| Abstract: | |
| Keywords: | essential hypertension calming liver and restraining the Yang formula mild or moderate degree clinical study |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
