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| 热毒宁注射液治疗社区获得性肺炎疗效的Meta分析 | |
| 引用本文： | 高万朋,王时光,崔壮,曹洁,田恒勇.热毒宁注射液治疗社区获得性肺炎疗效的Meta分析[J].中国中药杂志,2011,36(24):3539-3543. |
| 作者姓名： | 高万朋 王时光 崔壮 曹洁 田恒勇 |
| 作者单位： | 1. 天津中医药大学第二附属医院急诊科,天津,300150 2. 天津医科大学统计学教研室,天津,300052 3. 天津医科大学总医院呼吸科,天津,300052 4. 江苏康缘药业股份有限公司,江苏连云港,222001 |
| 摘 要： | 目的:评价热毒宁注射液治疗社区获得性肺炎( community-acquired pneumonia,CAP)的疗效和安全性.方法:广泛收集热毒宁注射液治疗CAP随机对照试验文献,用Jadad评分表评价纳入文献的质量.对纳入的试验作系统评价.结果:符合纳入标准的文献共7篇.Meta分析结果显示,热毒宁与抗生素联合治疗组与抗生素治疗组相比,治愈率相对危险度(relative risk,RR)为1.34,95％可信区间(confidence interval,CI)1.19,1.51]；总有效率RR为1.10,95％ CI 1.06,1.15].退热时间均数差(mean difference,MD)为- 1.42,95％CI -2.58,-0.26]；咳嗽好转时间MD -2.36,95％ CI -3.41,-1.31];肺部啰音改善时间MD -2.30,95％CI -2.61,-2.00]；胸部X线阴影吸收好转率MD为-2.36,95％CI -2.52,-2.20].2组上述各指标比较,差异均有统计学意义.未报道热毒宁注射液临床应用相关的严重不良反应.结论:当前证据表明在有效抗生素及常规对症治疗的基础上联合热毒宁注射液治疗CAP可以提高临床疗效,减轻咳嗽咳痰的症状,缩短发热时间,加速胸片阴影的吸收,且未见明显不良反应.但是由于纳入的研究质量所限,尚需要进行更多高质量的研究做进一步分析. |
| 关 键 词： | 热毒宁注射液 社区获得性肺炎 系统评价 meta分析 |
| 收稿时间： | 2011/4/11 0:00:00 |
Reduning injection for community-acquired pneumonia:meta-analysis |
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| GAO Wanpeng,WANG Shiguang,CUI Zhuang,CAO Jie and TIAN Hengyong.Reduning injection for community-acquired pneumonia:meta-analysis[J].China Journal of Chinese Materia Medica,2011,36(24):3539-3543. | |
| Authors: | GAO Wanpeng WANG Shiguang CUI Zhuang CAO Jie and TIAN Hengyong |
| Affiliation: | GAO Wanpeng1,WANG Shiguang1*,CUI Zhuang2,CAO Jie3,TIAN Hengyong4 (1.Department of Emergency,the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300150,China,2.Health Statistics Teaching and Research Section,Public Health College,Tianjin Medical University,Tianjin 300052,3.Division of respiratory medicine,Tianjin Medical University General Hospital,China 4.Jiangsu Kanion Pharmaceutical Co.,Ltd.,Lianyungang 222001,China) |
| Abstract: | Objective: To evaluate the efficacy and safety of Reduning injection for treating community-acquired pneumonia. Method: Literatures about randomized controlled trials of Reduning injection for treating community-acquired pneumonia were reviewed. The methodological quality of the trials was assessed by the Jadad scale, and evaluation was performed. Result: Seven RCTS were included. Reduning combined group (Reduning injection plus antibiotics and basic therapy) was compared with antibiotics group(antibiotics plus basic therapy). Meta-analysis showed that the relative risk(RR)for the total cure rate was 1.34, and 95%confidence interval (CI) was ; RR for the total effective rate was 1.10, and 95% CI was . The weighted mean difference (WMD) in disappearance time of fever between the two groups was -1.42, and 95%CI was ;The WMD between the two groups for the total obvious effect rate of cough and expectoration were -2.36, and 95%CI was ; Improve the time of pulmonary rales MD -2.30, 95%CI ; The WMD between the two groups in absorption of chest x-ray shadow was -2.36 and 95%CI . Serious systematic adverse reactions had not been reported in the trials. Conclusion: The effect of combined therapy with Reduning injection plus antibiotics and basic therapy is better than that of antibiotics plus basic therapy. Reduning injection can improve the symptoms of cough and expectoration, shorten the fever time and facilitate the absorption of chest x-ray shadow without any significant adverse reactions. However, further high quality trials are needed. |
| Keywords: | Reduning injection community-acquired pneumonia systematic review Meta-analysis |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ | |
