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马钱子总生物碱复合磷脂脂质体的药剂学性质研究
引用本文:陈军,张婷,蔡宝昌,陈明磊,方芸.马钱子总生物碱复合磷脂脂质体的药剂学性质研究[J].中国中药杂志,2010,35(1):35-39.
作者姓名:陈军  张婷  蔡宝昌  陈明磊  方芸
作者单位:1. 南京中医药大学,药学院,江苏,南京,210046;江苏省中药炮制重点实验室,江苏,南京,210029
2. 南京中医药大学,药学院,江苏,南京,210046
3. 江苏省中药炮制重点实验室,江苏,南京,210029
4. 南京大学医学院,附属鼓楼医院药剂科,江苏,南京,210008
基金项目:国家自然科学基金项目(30701111)
摘    要:目的:制备了以氢化大豆磷脂(HSPC)和普通大豆磷脂(SPC)为膜材的马钱子总生物碱复合磷脂脂质体,并与相应的单一磷脂脂质体比较药剂学性质。方法:采用浸渍法提取马钱子总生物碱并进行了纯化。采用硫酸铵梯度法和隐形脂质体技术制备了马钱子总生物碱复合磷脂脂质体和相应的2种单一磷脂(HSPC,SPC)脂质体,比较了3者的包封率、粒径、电位、释放度等性质。结果:HSPC-SPC(1∶3)为载药效果最好的复合磷脂比例。当药脂质量比为1∶6时,马钱子总生物碱复合磷脂、SPC和HSPC脂质体的包封率分别为(73.6±2.9)%,(62.9±1.8)%和(54.7±1.0)%(n=3)。与2种单一磷脂脂质体相比,马钱子总生物碱复合磷脂脂质体粒径明显减小但电位没有差别。释放度显著提高,但加入大鼠血浆后,复合磷脂脂质体的释放度显著低于SPC脂质体。结论:考虑到包封率提高、血液中稳定以及磷脂的价格,作为中药抗肿瘤药物载体,复合磷脂脂质体比相应的单一磷脂脂质体更具有开发价值。

关 键 词:马钱子  总生物碱  隐形脂质体  释放度  氢化大豆磷脂  大豆磷脂
收稿时间:2009/10/2 0:00:00

Pharmaceutical properties of novel liposomes containing total alkaloidsfrom seed of Strychnos nux-vomica
CHEN Jun,ZHANG Ting,CAI Baochang,CHEN Minglei and FANG Yun.Pharmaceutical properties of novel liposomes containing total alkaloidsfrom seed of Strychnos nux-vomica[J].China Journal of Chinese Materia Medica,2010,35(1):35-39.
Authors:CHEN Jun  ZHANG Ting  CAI Baochang  CHEN Minglei and FANG Yun
Affiliation:College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China;Jiangsu Key Laboratory of Chinese Medicine Processing, Nanjing 210029, China;College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China;Jiangsu Key Laboratory of Chinese Medicine Processing, Nanjing 210029, China;College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China;Department of Pharmacy, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China
Abstract:Objective: To prepare the novel liposomes composed of hydrogenated soybean phosphatidylcholine(HSPC) and soybean phosphatidylcholine(SPC) containing the total alkaloids from seed of Strychnos nux-vomica,and to compare the pharmaceutical properties of the novel liposomes with the corresponding HSPC or SPC liposomes.Method: The total alkaloids were extracted from seeds of S.nux-vomica.and further purified.Novel liposomes containing the total alkaloids were prepared by ammonium sulfate transmembrane gradients ...
Keywords:Strychnos nux-vomica  total alkaloids  stealth liposomes  drug release profile  HSPC  SPC
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