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蒙古蒲公英化学成分研究
引用本文:姚巍,林文艳 ,周长新,赵昱.蒙古蒲公英化学成分研究[J].中国中药杂志,2007,32(10):926-929.
作者姓名:姚巍  林文艳  周长新  赵昱
作者单位:1. 浙江化工科技集团有限公司,浙江,杭州,310023
2. 浙江大学,药学院,中药与天然药物研究室,浙江,杭州,310031
摘    要:目的:研究蒙古蒲公英的化学成分。方法:应用硅胶柱色谱,Sephadex LH-20凝胶柱色谱及RP-18反相色谱进行分离纯化,并通过理化和波谱方法鉴定其结构。结果:分离得到8个化合物,经理化及波谱数据分析鉴定为青蒿亭(1),槲皮素(2),木犀草素(3),木犀草素7-O-β-D葡萄糖苷(4),咖啡酸(5),七叶内酯(6),豆甾醇(7),蒲公英甾醇乙酯(8)。结论:化合物1为首次从该属植物中分到,化合物6,8为首次从该种植物分到,同时运用2D-NMR技术对化合物6的文献碳谱数据进行了纠正。

关 键 词:蒙古蒲公英  青蒿亭  七叶内酯  蒲公英甾醇乙酯
文章编号:1001-5302(2007)10-0926-04
收稿时间:2006-08-23
修稿时间:2006-08-23

Studies on constitutes from Taraxacum mongolicum
YAO Wei; LIN Wen-yan; ZHOU Chang-xin; ZHAO Yu.Studies on constitutes from Taraxacum mongolicum[J].China Journal of Chinese Materia Medica,2007,32(10):926-929.
Authors:YAO Wei; LIN Wen-yan; ZHOU Chang-xin; ZHAO Yu
Affiliation:1. Zhejiang Chem-Tech Group Co. , Ltd. , Hangzhou 310023, China; 2. Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, China
Abstract:OBJECTIVE: To study the chemical constituents of Taraxacum mongolicum. METHOD: Repeated column chromatography over silica gel, C-18 and Sephadex LH-20 were used to isolate chemical constitutes and their structures were elucidated by spectroscopic methods MS, 1H-NMR, 13C-NMR including 2D-NMR techniques and by direct comparing spectral data with those reported in literatures. RESULT: Eight compounds were identified as artemetin (1), quercetin (2), luteolin (3), luteolin-7-O-beta-D-glucopyranoside (4), caffeic acid (5), esculetin (6), stigmasterol (7), taraxasteryl acetate (8), respectively. CONCLUSION: Compound 1 was obtained from this genus and compound 6, 8 from this species for the first time. Furthermore, the 13 carbon data of compound 6 from the literature were corrected with 2D-NMR techniques in this paper.
Keywords:Taraxacum mongolicum  artemetin  esculetin  taraxasteryl acetate
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