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近红外漫反射光谱法用于白芍配方颗粒原料药材质量控制的研究
引用本文:涂瑶生,柳俊,孙冬梅,张建军,毕晓黎.近红外漫反射光谱法用于白芍配方颗粒原料药材质量控制的研究[J].中国中药杂志,2011,36(9):1162-1167.
作者姓名:涂瑶生  柳俊  孙冬梅  张建军  毕晓黎
作者单位:1. 广州中医药大学,广东,广州,510405;广东省中医研究所,广东,广州,510095
2. 广东省中医研究所,广东,广州,510095
摘    要:目的:提出一种快速、无损检测白芍药材中芍药苷、芍药内酯苷及水分的新方法.方法:运用偏最小二乘法(PLS)建立近红外光谱(NIR)与芍药苷、芍药内酯苷和水分测定值之间的多元校正模型,对未知样品进行含量预测.结果:校正模型相关系数(R2)分别为0.938,0.943,0.976.验证集预测平均相对偏差分别为6.5%,0.23%,3.8%.结论:近红外光谱法具有分析速度快、预测结果准确、不破坏样品和不污染环境等优点,而且不需要对样品进行复杂繁琐的前处理,适合对组成复杂的中药进行快速分析,可用于白芍配方颗粒原料药材的质量监控.

关 键 词:近红外漫反射光谱法  白芍配方颗粒  白芍药材  质量控制
收稿时间:2010/10/9 0:00:00

Study on quality control of herbal material of paeony formula granule by near infrared diffuse reflection spectroscopy
TU Yaosheng,LIU Jun,SUN Dongmei,ZHANG Jianjun and BI Xiaoli.Study on quality control of herbal material of paeony formula granule by near infrared diffuse reflection spectroscopy[J].China Journal of Chinese Materia Medica,2011,36(9):1162-1167.
Authors:TU Yaosheng  LIU Jun  SUN Dongmei  ZHANG Jianjun and BI Xiaoli
Affiliation:Guangzhou University of Chinese Medicine, Guangzhou 510405, China;Guangdong Provincial Institute of Traditional Chinese Medicine, Guangzhou 510095, China;Guangzhou University of Chinese Medicine, Guangzhou 510405, China;Guangdong Provincial Institute of Traditional Chinese Medicine, Guangzhou 510095, China;Guangzhou University of Chinese Medicine, Guangzhou 510405, China;Guangdong Provincial Institute of Traditional Chinese Medicine, Guangzhou 510095, China;Guangdong Provincial Institute of Traditional Chinese Medicine, Guangzhou 510095, China;Guangdong Provincial Institute of Traditional Chinese Medicine, Guangzhou 510095, China
Abstract:Objective : To develop a novel method to determine fastly and nondestructively the content of paeoniflorin, albiflorin and moisture in Radix Paeoniae Alba with near infrared diffuse reflection spectroscopy. Method: Multivariate calibration models based on PLS algorithm were developed to correlate the spectra and the corresponding values determined by the reference method. Result: The corelation coefficients (R2) of the calibration models were 0.938, 0.943 and 0.976,and the prediction average relative deviation for paeoniflorin, albiflorin and moisture content were 6.5%, 0.23% and 3.8%, respectively. Conclusion: The NIRS determination method is rapid, accurate, nondestructive and non-pollution. It can dispose the samples without complicated pretreatment.It is qualified to analyze rapidly traditional Chinese medicine whose components are complex. NIRS can be used to control the quality of herbal material of paeony formula granule.
Keywords:near infrared diffuse reflection spectroscopy  paeony formula granule  radix paeoniae alba  quality control
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