| 龙葵抗肿瘤作用机制研究进展 |
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| 引用本文： | 安磊,唐劲天,刘新民,高南南.龙葵抗肿瘤作用机制研究进展[J].中国中药杂志,2006,31(15):1225-1226. |
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| 作者姓名： | 安磊 唐劲天 刘新民 高南南 |
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| 作者单位： | 1. 中国医学科学院,中国协和医科大学,药用植物研究所,北京,100094
2. 清华大学,医学物理与工程研究所,北京,100084 |
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| 基金项目： | 国家重点基础研究发展计划(973计划) |
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| 摘 要： | 对近年来龙葵抗肿瘤的活性成分及作用机制进行综述。大量实验研究表明龙葵碱可通过改变细胞膜的结构和功能、影响DNA和RNA的合成以及改变细胞周期分布来抑制肿瘤。龙葵糖蛋白（150×103）可通过阻断NF-κB抗调亡通路、激活caspase级联反应、及促进NO的释放促进肿瘤细胞的调亡。
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| 关 键 词： | 龙葵 抗肿瘤 作用机制 |
| 文章编号： | 1001-5302（2006）15-1225-03 |
| 收稿时间： | 2/9/2006 12:00:00 AM |
| 修稿时间： | 2006-02-09 |
Review about mechanisms of anti-cancer of Solanum nigrum |
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| AN Lei ;TANG Jin-tian ;LIU Xin-min;GAO Nan-nan.Review about mechanisms of anti-cancer of Solanum nigrum[J].China Journal of Chinese Materia Medica,2006,31(15):1225-1226. |
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| Authors: | AN Lei ;TANG Jin-tian ;LIU Xin-min;GAO Nan-nan |
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| Affiliation: | Institute of Medicinal Plant Devlopment, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. |
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| Abstract: | This paper gave a brief introduction of the effect of Solanum nigrum on anti-cancer. The experimental results showed that the total alkaloid isolated from S. nigrum interfered structure and function of tumor cell membrane, disturbed the synthesis of DNA and RNA, changed the cell cycle distribution, so that total alkaloids could play in inhibabition to tumor cells, while the glycoprotein (150 x 10(3)) isolated from S. nigrum might have shown anti-cancer abilities by blocking the anti-apoptotic pathway of NF-kappaB, activating caspase cascades reaction and increasing the production of nitric oxide. |
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| Keywords: | Solanum nigrum anti-cancer mechanism |
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