| 基于中草药的天然防霉剂的研究进展与剂型开发 |
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| 引用本文： | 王海威,应光耀,杨志欣,杨美华,刘佳佳,范卓文,孔维军.基于中草药的天然防霉剂的研究进展与剂型开发[J].中国中药杂志,2017,42(7):1251-1257. |
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| 作者姓名： | 王海威 应光耀 杨志欣 杨美华 刘佳佳 范卓文 孔维军 |
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| 作者单位： | 中国医学科学院 北京协和医学院 药用植物研究所, 北京 100193;黑龙江中医药大学 药学院, 黑龙江 哈尔滨 150040,中国医学科学院 北京协和医学院 药用植物研究所, 北京 100193;锦州医科大学 药学院, 辽宁 锦州 121001,黑龙江中医药大学 药学院, 黑龙江 哈尔滨 150040,中国医学科学院 北京协和医学院 药用植物研究所, 北京 100193,黑龙江中医药大学 药学院, 黑龙江 哈尔滨 150040,黑龙江中医药大学 药学院, 黑龙江 哈尔滨 150040,中国医学科学院 北京协和医学院 药用植物研究所, 北京 100193 |
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| 基金项目： | 国家自然科学基金项目（81473346，81673593，81573595）；中国医学科学院医学与健康科技创新工程项目（2016-I2M-3-010） |
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| 摘 要： | 食品、农产品和中药材等基质,受其自身因素及外界环境条件的影响,在种植、采收、加工、贮藏过程中若处理不当,极易污染霉菌,进而产生具有严重毒性作用的真菌毒素,不仅会影响其质量和安全性、有效性,也会对人体及动物健康甚至生命造成威胁。所以,近年来从源头上防控食品、农产品、中药材的霉变产毒,做好科学养护已成为人们关注的焦点。许多中草药尤其挥发油含量较高的中草药具有较强的抑菌杀菌活性,已被应用于食品、农产品、中药材等基质的防霉变科学养护中。基于此,进一步将其开发为天然防霉剂并制成一定的剂型,如片剂、气雾剂、脂质体、包合物等,不仅大大拓展了中草药的应用范围,方便防霉剂的使用,也能达到缓释或控释的防霉效果和科学养护的目的,具有广阔的开发前景。
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| 关 键 词： | 中草药 天然防霉剂 挥发油 剂型开发 |
| 收稿时间： | 2016/11/30 0:00:00 |
Research progresses and formulation development of natural anti-mildew agents based on Chinese herbal medicines |
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| WANG Hai-wei,YING Guang-yao,YANG Zhi-xin,YANG Mei-hu,LIU Jia-ji,FAN Zhuo-wen and KONG Wei-jun.Research progresses and formulation development of natural anti-mildew agents based on Chinese herbal medicines[J].China Journal of Chinese Materia Medica,2017,42(7):1251-1257. |
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| Authors: | WANG Hai-wei YING Guang-yao YANG Zhi-xin YANG Mei-hu LIU Jia-ji FAN Zhuo-wen and KONG Wei-jun |
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| Affiliation: | Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China;College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China,Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China;College of Pharmacy, Jinzhou Medical University, Jinzhou 121001, China,College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China,Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China,College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China,College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China and Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China |
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| Abstract: | Owing to the intrinsic factors and some extrinsic environmental conditions, many foods, agricultural products and Chinese materia medicas (CMMs), if not handled properly in the processes of growth, harvesting, processing and storage, can be easily contaminated by all kinds of molds to produce mycotoxins of serious toxicity, which will not only affect the quality, safety and effectiveness of CMMs, but also result in potential threatens to human and animal''s health and life. Therefore, in recent decades, it has become the focus on how to prevent and control the foods, agricultural products and CMMs from being moldy and producing toxicity for scientific preservation. Many Chinese herbal medicines (CHMs) especially those with high content of volatile oils with strong antifungal activities have been applied for the scientific preservation of foods, agricultural products and CMMs. Based on these situations, natural anti-mildew agents have been further developed and made into some useful dosage forms, such as tablets, aerosol, liposomes and inclusion, which will not only greatly expand the application scope of CHMs to make the use of anti-mildew agents more convenient, but also achieve the sustained or controlled release of the antifungal effect for scientific preservation of foods, agricultural products and CMMs. |
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| Keywords: | Chinese herbal medicine natural anti-mildew agents volatile oil formulation development |
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