| 天钩降压胶囊对肾血管性高血压大鼠血压的影响 |
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| 引用本文： | 杨庆,李玉洁,刘晓霓,翁小刚,陈颖,朱晓新,韩晓,邹丽娟,李丹.天钩降压胶囊对肾血管性高血压大鼠血压的影响[J].中国中药杂志,2011,36(23):3344-3348. |
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| 作者姓名： | 杨庆 李玉洁 刘晓霓 翁小刚 陈颖 朱晓新 韩晓 邹丽娟 李丹 |
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| 作者单位： | 中国中医科学院中药研究所,北京,100700 |
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| 基金项目： | 国家"重大新药创制"科技重大专项(2009ZX09103-403) |
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| 摘 要： | 目的:观察天钩降压胶囊对肾血管性高血压大鼠的血压的影响并初步探讨其作用机制.方法:将72只Wistar大鼠随机分为正常对照组、模型组、卡托普利组(0.03 g·kg-1)、天钩降压胶囊低、中、高剂量组(5.4,10.8,21.6g· kg-1).采用无创血压仪测量鼠尾动脉血压；采用放射免疫法测定大鼠血中PRA,AngⅡ,ALD,6-酮-前列腺F1α,ET和TXB2的含量；采用硝酸还原酶法测定大鼠血中NO的含量.结果:模型组收缩压、舒张压和平均压明显升高,大鼠血中PRA,AngⅡ,ALD明显降低,ET水平明显增高；天钩降压胶囊能明显降低模型大鼠的血压,提高大鼠血中肾素活性,降低大鼠血中ET含量,升高NO含量.结论:天钩降压胶囊具有降低肾性高血压模型大鼠血压的作用,其降低血压的机制可能与其调控模型大鼠RAAS系统的分泌以及改善血管内皮的功能有关.
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| 关 键 词： | 肾血管性高血压 肾素-血管紧张素-醛固酮系统 血管内皮功能 天钩降压胶囊 |
| 收稿时间： | 2010/11/4 0:00:00 |
Influence of Tiangou Jiangya capsule on blood pressure in renovascular hypertension rats |
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| YANG Qing,LI Yujie,LIU Xiaoni,WENG Xiaogang,CHEN Ying,ZHU Xiaoxin,HAN Xiao,ZOU Lijuan and LI Dan.Influence of Tiangou Jiangya capsule on blood pressure in renovascular hypertension rats[J].China Journal of Chinese Materia Medica,2011,36(23):3344-3348. |
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| Authors: | YANG Qing LI Yujie LIU Xiaoni WENG Xiaogang CHEN Ying ZHU Xiaoxin HAN Xiao ZOU Lijuan and LI Dan |
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| Affiliation: | Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China |
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| Abstract: | |
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| Keywords: | renovascular hypertension renin-angiotensin-aldosterone system vascular endothelial function Tiangou Jiangya capsule |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
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