| 天南星科4种有毒中药针晶的晶型结构和其毒性的比较 |
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| 引用本文： | 吴皓,葛秀允,郁红礼,陈琳.天南星科4种有毒中药针晶的晶型结构和其毒性的比较[J].中国中药杂志,2010,35(9):1152-1155. |
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| 作者姓名： | 吴皓 葛秀允 郁红礼 陈琳 |
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| 作者单位： | 南京中医药大学,药学院,江苏省中药炮制重点实验室,江苏,南京,210029 |
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| 基金项目： | 国家自然科学基金项目(30772785,30973939);国家"十一五"科技支撑计划(2006BAI09B06 -10) |
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| 摘 要： | 目的:研究天南星科4种有毒中药的针晶是否为具有共性的毒性成分.方法:提取分离半夏、天南星、禹白附、虎掌南星的针晶,采用电镜扫描2万倍观察各针晶的晶体结构,采用X-衍射能谱分析各针晶的主要组成元素,采用红外光谱定性测定针晶成分的主要基团,采用急性毒性实验研究4种针晶和相应生品的急性毒性,以Bliss法计算各样品的LD50.结果:4种有毒中药的针晶均为细长尖锐针样晶型,直径小于1 μm,晶体表面布满倒刺,中间有凹槽,以半夏属的半夏和虎掌南星针晶更为锋利和尖锐;4种针晶中主要含有Ca,C,O,N,S元素,红外光谱显示针晶中含有-COOH,-NH2基团;说明针晶不仅仅是由草酸钙组成;4种有毒中药的针晶可以产生严重的毒性反应,LD50分别为:半夏针晶14.78 mg·kg-1,虎掌南星针晶14.11 mg·kg-1,天南星针晶16.02 mg·kg-1,禹白附针晶18.90 mg·kg-1,而其相应生品的LD50从半夏到禹白附均在3 300 mg·kg-1以上,针晶的毒性是相应生品毒性的200倍.结论:半夏、天南星、禹白附及虎掌南星中所含有的针晶是4种有毒中药中具有共性的毒性成分.
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| 关 键 词： | 天南星科 针晶结构 毒性 |
| 收稿时间： | 9/2/2009 12:00:00 AM |
Comparisons of crystal form of raphides to toxicity raphidesin four poisonous herbs of Araceae family |
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| WU Hao,GE Xiuyun,YU Hongli and CHEN Lin.Comparisons of crystal form of raphides to toxicity raphidesin four poisonous herbs of Araceae family[J].China Journal of Chinese Materia Medica,2010,35(9):1152-1155. |
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| Authors: | WU Hao GE Xiuyun YU Hongli and CHEN Lin |
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| Affiliation: | Jiangsu Key Laboratory of Processing Preparaing of Chinese Medicines, School of Pharmacy,Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China;Jiangsu Key Laboratory of Processing Preparaing of Chinese Medicines, School of Pharmacy,Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China;Jiangsu Key Laboratory of Processing Preparaing of Chinese Medicines, School of Pharmacy,Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China;Jiangsu Key Laboratory of Processing Preparaing of Chinese Medicines, School of Pharmacy,Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China |
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| Abstract: | Objective:To compare the crystal form with the toxicity intensitity of raphides in four poisonous herbs of Araceae family.Method: The four kinds of raphides were extracted and isolated from Pinellia ternate, P. pedatisecta, Arisaema amurense and Typhonium giganteum. These raphides were observed with scanning electron microscopy (SEM), and the elements were analyzed with X-ray photoelectron spectroscopy.Infrared spectrum was used for detecting the functional groups.Toxic intensities of the four kinds of raph... |
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| Keywords: | Araceae crystal form raphides toxicity |
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