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厚朴和凹叶厚朴对实验性胃肠动力障碍的药效作用差异研究
引用本文:彭博,贺蓉,杨滨,路艳丽,高杰,李建荣.厚朴和凹叶厚朴对实验性胃肠动力障碍的药效作用差异研究[J].中国中药杂志,2010,35(19):2624-2627.
作者姓名:彭博  贺蓉  杨滨  路艳丽  高杰  李建荣
作者单位:中国中医科学院,中药研究所,北京100700
基金项目:2007年度中医药行业科研专项(200707007)
摘    要:目的:比较厚朴和凹叶厚朴缓解实验性胃肠动力障碍的药效。方法:采用左旋精氨酸和硫酸阿托品诱导的鼠胃肠动力障碍模型。观察给予厚朴和凹叶厚朴水煎剂后炭末排出时间?胃内残留率、小肠推进率、血清D-木糖含量、血清胃动素(MTL)和胃泌素(GAS)含量的改变。同时应用Bliss法计算ED50。结果:厚朴和凹叶厚朴均能不同程度的缓解实验性胃肠动力障碍,降低胃内残留率、促进小肠推进率、增加血清D-木糖含量及血清MTL和GAS水平;并且按上述指标计算出2种药物的ED50,发现厚朴凹叶厚朴。结论:同凹叶厚朴相比,厚朴缓解胃肠运动功能障碍的作用较优。

关 键 词:厚朴  胃肠动力障碍模型  胃动素  胃泌素  ED50
收稿时间:2009/12/28 0:00:00

Comparative study of effect of Magnolia officinalis and M. officinalis var. biloba on gastrointestinal motility dysfunction
PENG Bo,HE Rong,YANG Bin,LU Yanli,GAO Jie and LI Jianrong.Comparative study of effect of Magnolia officinalis and M. officinalis var. biloba on gastrointestinal motility dysfunction[J].China Journal of Chinese Materia Medica,2010,35(19):2624-2627.
Authors:PENG Bo  HE Rong  YANG Bin  LU Yanli  GAO Jie and LI Jianrong
Affiliation:Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700,China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700,China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700,China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700,China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700,China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700,China
Abstract:Objective : To compare the effect of Magnolia officinalis and M. officinalis var. biloba on gastrointestinal motility dysfunction. Method : The gastrointestinal motility dysfunction induced by atropine and L-Arg were used in this study. The effect of M. officinalis on the gastrointestinal function was evaluated by propulsive motility of the total gastrointestinal tract test by recording the time of excreting carbo medicinalis, the gastric residualrate, the intestinal propulsion rate, the serum levels of D-xylose, motilin(MTL) and gastrin(GAS). ED50 were calculated with Bliss's method. Result : M. officinalis and M. officinalis var. biloba improved the gastrointestinal motility, decreased the gastric residual rate, enhanced the intestinal propulsion rate and increased serum levels of D-xylose, motilin(MTL) and gastrin(GAS). The ED50 value of M. officinalis var. biloba was much higher than that of M. officinalis. Conclusion : The effect of improving gastrointestinal motility of M. officinalis was proved to be superior to that of M. officinalis var. biloba.
Keywords:Magnoliae Officinalis gastrointestinal motility dysfunction  motilin  gastrin  ED50
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