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参附注射液对心肌缺血犬血流动力学和对动物血压的影响
引用本文:杨芳炬,王正荣,林代平,屈艺,尹华虎,史立丽,郭惠玲,肖静,王跃奇,刘荣韬.参附注射液对心肌缺血犬血流动力学和对动物血压的影响[J].中国中药杂志,2003,28(3):259-262.
作者姓名:杨芳炬  王正荣  林代平  屈艺  尹华虎  史立丽  郭惠玲  肖静  王跃奇  刘荣韬
作者单位:四川大学,华西基础医学与法医学院,四川,成都,610041
摘    要:目的 :观察参附注射液对心肌缺血犬血流动力学和对犬、大鼠血压的影响。方法 :结扎犬左冠状动脉前降支造成心肌缺血及低血压 ;缩窄大鼠腹主动脉造成血管阻力增加而形成继发性高血压 ;分别给予参附注射液5 ,10mL·kg-1,观察其对犬血流动力学和对动物正常血压或高血压的影响。结果与结论 :参附注射液使心肌缺血犬的心脏做功能力显著提高 ,在不明显增加心肌耗氧量情况下使心收缩力增强 ,心输出量增加 ;并使心肌缺血所致的血压降低出现明显的回升作用 ;而对继发性高血压和正常动物血压无明显影响。

关 键 词:参附注射液  心肌缺血  心功能  血流动力学  继发性高血压
文章编号:1001-5302(2003)03-0259-04
收稿时间:2001/9/11 0:00:00
修稿时间:2001年9月11日

The Influence on Hemodynamecs of Myocardial Ischemic Dogs and Blood Pressure of Animals With Shenfu Injection
YANG Fang ju;WANG Zheng rong;LIN Dai ping;QU Yi;YIN Hua hu;SHI Li li;GUO Hui ling;XIAO Jing;WANG Yue qi;LIU Rong tao.The Influence on Hemodynamecs of Myocardial Ischemic Dogs and Blood Pressure of Animals With Shenfu Injection[J].China Journal of Chinese Materia Medica,2003,28(3):259-262.
Authors:YANG Fang ju;WANG Zheng rong;LIN Dai ping;QU Yi;YIN Hua hu;SHI Li li;GUO Hui ling;XIAO Jing;WANG Yue qi;LIU Rong tao
Affiliation:School of Basic Medical Science and Medical Jurisprudence of Sichuan University, Chengdu 610041, Sichuan, China. yang Fangju hotmail
Abstract:Objective:To investigate the influence of Shenfu injection on the hemodynamic indexes of myocardial ischemic dogs and blood pressure of dogs and rats. Method:Myocardial ischemic model was made and hypotension in the dogs was induced with ligating left front descending limb coronary artery method, and secondary hypertension by narrowing nephridium artery of rats, Shenfu injection was administered with 5, 10mL·kg-1 to the above dogs and rats separately to investigate the influence of it on the hemodynamic indexes of myocardial ischemic dogs and blood pressure of rats. Result and Conclusion:Shenfu injection enhanced the capacity of myocardial work markedly; it augmented the myocardium contractility and cardiac output without raising the oxygen consume, and at the same time it returned normal the blood pressure in myocardial ischemic; but it had no effects on the normal blood pressure and secondary hypertension of rats.
Keywords:Shenfu injection  myocardial ischemic  capacity of cardiac work  hemodynamic  secondary hypertension
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