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牡丹皮化学成分研究
引用本文:胡红宇,杨郁,于能江,赵毅民.牡丹皮化学成分研究[J].中国中药杂志,2006,31(21):1793-1795.
作者姓名:胡红宇  杨郁  于能江  赵毅民
作者单位:军事医学科学院,毒物药物研究所,北京,100850
摘    要:目的:研究牡丹皮的化学成分。方法:药材采用95%乙醇提取,醋酸乙酯萃取,利用硅胶柱色谱,Sephadex LH-20凝胶柱色谱,RP-18反相柱色谱分离纯化,并根据理化性质和波谱数据进行结构鉴定。结果:分离鉴定6个化合物,分别为(+)-儿茶素(1),paeonidanin(2),paeoniflorigenone(3),2,5-二羟基-4-甲氧基苯乙酮(4),丹皮酚(5),没食子酸(6)。结论:化合物1为从该属中首次分离得到,化合物2,3为从该植物首次中分离得到。

关 键 词:牡丹皮  化学成分
文章编号:1001-5302(2006)21-1793-03
收稿时间:4/1/2006 12:00:00 AM
修稿时间:2006-04-01

Study on chemical constituents of bark of Paeonia suffruticosa
HU Hong-yu;YANG Yu;YU Neng-jiang;ZHAO Yi-min.Study on chemical constituents of bark of Paeonia suffruticosa[J].China Journal of Chinese Materia Medica,2006,31(21):1793-1795.
Authors:HU Hong-yu;YANG Yu;YU Neng-jiang;ZHAO Yi-min
Affiliation:Institute of Pharmacology and Toxicology, Academy of Military Medical Science, Beijing 100850, China
Abstract:Objective: To study the chemical constituents of the bark of Paeonia suffruticosa. Method: The 95% ethanol extract was re-extracted with EtOAc, and then separated and purified by column chromatography using silica gel, Sephadex LH-20 and RP-18 as packing materials. The structures were identified on the basis of spectral analysis and physico-chemical characters. Result: Six compounds were isolated and identified as (+)-catechin (1), paeonidanin (2), paeoniflorigenone (3), 2, 5-dihydroxy-4-methoxyacetophenone (4), paeonol (5), gallic acid (6). Conclusion: The compound 1 was isolsted from the genus Paeonia for the first time. The compounds 2, 3 were isolated from this plant for the first time.
Keywords:Paeonia suffruticosa  chemical constituent
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