| 基于全局非靶向代谢组学对黄蜀葵不同部位成分的差异分析 |
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| 引用本文： | 杨晓男,胡营,韦坤华,刘拾生,缪剑华.基于全局非靶向代谢组学对黄蜀葵不同部位成分的差异分析[J].中国现代中药,2023,25(7):1592-1598. |
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| 作者姓名： | 杨晓男 胡营 韦坤华 刘拾生 缪剑华 |
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| 作者单位： | 1.广西壮族自治区药用植物园 广西药用资源保护与遗传改良重点实验室/广西壮族自治区中药资源 智慧创制工程研究中心，广西 南宁 530023;2.深圳市农科蔬菜科技有限公司，广东 深圳 518118 |
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| 基金项目： | 广西创新驱动发展专项（桂科AA18242040）；广西科技基地和人才专项（桂科AD22080012）；广西壮族自治区药用植物园广西药用资源保护与遗传改良重点实验室自主课题（KL2022ZZ01）；对发展中国家科技援助项目（KY201904001）；科技基础资源调查专项（2018FY100700）；财政部和农业农村部：国家现代农业产业技术体系资助项目；广西农业科技创新联盟项目（桂农科盟202211）；广西壮族自治区中医药管理局自筹经费项目（GXZYZ20210016） |
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| 摘 要： | 目的 通过代谢组学分析黄蜀葵叶、茎、根、花中主要化学成分及其相对含量，为提高黄蜀葵的药用和经济价值提供科学基础。方法 使用超高效液相色谱-质谱联用法对黄蜀葵各部位代谢物进行定性分析，通过全局非靶向代谢组学方法分析比较黄蜀葵不同部位主要代谢物的相对含量。结果 黄蜀葵主要功效成分黄酮类物质在叶、茎、根中也有大量分布，其中标志性化合物金丝桃苷在黄蜀葵叶中的相对含量最高。其他类活性成分，如生物碱、香豆素、萜类、氨基酸等在黄蜀葵叶中的相对含量也较高。结论 除了黄蜀葵花，其他部位如叶、茎、根中也含有较多的活性成分，在提取利用其中的活性成分时可以考虑全株提取或有针对性地部位提取，以提高黄蜀葵的药用及经济价值，减少资源浪费。
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| 关 键 词： | 黄蜀葵 非靶向代谢组学 活性成分 提高利用率 |
| 收稿时间： | 2022/11/9 0:00:00 |
Differential Analysis of Components in Different Parts of Abelmoschus manihot (L.) Medicus Based on Global Untargeted Metabolomics |
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| YANG Xiao-nan,HU Ying,WEI Kun-hu,LIU Shi-sheng,MIAO Jian-hua.Differential Analysis of Components in Different Parts of Abelmoschus manihot (L.) Medicus Based on Global Untargeted Metabolomics[J].Modern Chinese Medicine,2023,25(7):1592-1598. |
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| Authors: | YANG Xiao-nan HU Ying WEI Kun-hu LIU Shi-sheng MIAO Jian-hua |
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| Affiliation: | 1.Guangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement/Guangxi Engineering Research Center of TCM Resource Intelligent Creation, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China;2.Shenzhen Nongke Vegetable Science & Technology Co., Ltd., Shenzhen 518118, China |
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| Abstract: | Objective To analyze the main chemical components and their relative content in the leaves, stems, roots, and flowers of Abelmoschus manihot (L.) Medicus through metabolomics, providing a scientific basis for improving its medicinal and economic value.Methods Qualitative analysis of metabolites in different parts of A. manihot was conducted using ultra-high-performance liquid chromatography-mass spectrometry. The relative content of major plant metabolites in different parts of A. manihot were analyzed and compared using a global untargeted metabolomics approach.Results Flavonoids, the main active compounds in A. manihot, were found to be widely distributed in the leaves, stems, and roots, in addition to the flowers. Among them, the characteristic compound, hyperin, had the highest relative content in the leaves of A. manihot. Other active compounds such as alkaloids, coumarins, terpenoids, and amino acids also had relatively high content in the leaves of A. manihot.Conclusion In addition to the flowers, other parts of A. manihot, such as the leaves, stems, and roots, also contain a significant amount of active components. When extracting and utilizing these active compounds, it is advisable to consider extracting from the whole plant or specific parts to enhance the medicinal and economic value of A. manihot and reduce resource waste. |
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| Keywords: | Abelmoschus manihot (L ) Medicus untargeted metabolomics active components increase resource utilization rate |
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