| 体检人群血清M2型抗线粒体抗体流行率调查* |
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| 引用本文： | 曲颖,蔡晓波,张启迪,陆伦根.体检人群血清M2型抗线粒体抗体流行率调查*[J].实用肝脏病杂志,2022,25(2):203-206. |
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| 作者姓名： | 曲颖 蔡晓波 张启迪 陆伦根 |
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| 作者单位： | 200080 上海市 上海交通大学附属第一人民医院消化科 |
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| 基金项目： | 国家自然科学基金青年基金资助项目(编号81500463)。 |
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| 摘 要： | 目的 在健康体检人群中筛查原发性胆汁性胆管炎(PBC)的特异性抗体,即抗线粒体抗体(AMA)-M2,以了解其流行率。方法 2012年5月～2014年12月我院体检中心血清样本18515例,采用ELISA行AMA-M2定量检测,同时收集肝功能生化指标。结果 在筛查的18515名体检者中,245例(1.3%)血清AMA-M2阳性,男性97名,女性148名,男女比例约为1:1.5,46～55岁年龄段阳性比例率为28.6%;12名AMA-M2阳性者同时伴有血清ALP水平升高,符合中国PBC诊断和治疗共识的诊断标准;54例高滴度AMA-M2抗体(＞150U/ml)者血清ALP为(92.8±85.6 U/L),GGT水平为(84.3±118.5 U/L,显著高于191例低滴度组【分别为(67.7±38.3U/L)和(39.1±61.8U/L),P<0.05】。结论 健康体检人群血清AMA-M2抗体阳性并不少见,筛查AMA-M2抗体有助于早期识别PBC。
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| 关 键 词： | 原发性胆汁性胆管炎 抗线粒体抗体 筛查 诊断 |
| 收稿时间： | 2021-06-16 |
Prevalence of serum anti-mitochondrial antibody-M2 antibody in health check-up individuals |
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| Qu Ying,Cai Xiaobo,Zhang Qidi,et al.Prevalence of serum anti-mitochondrial antibody-M2 antibody in health check-up individuals[J].Journal of Clinical Hepatology,2022,25(2):203-206. |
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| Authors: | Qu Ying Cai Xiaobo Zhang Qidi |
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| Affiliation: | Department of Gastroenterology, Shanghai General Hospital, JiaoTong University School of Medicine, Shanghai 200080, China |
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| Abstract: | Objective The purpose of this study was to investigate the prevalence of serum anti-mitochondrial antibody-M2(AMA-M2)antibody in physical examination individuals.Methods 18515 serum samples were collected from the Physical Examination Center,Shanghai General Hospital between May 2012 and December 2014.Serum AMA-M2 was quantitatively detected by ELISA,and blood biochemical parameters were assayed.Results Among 18515 screened people,245 persons(1.3%)were serum AMA-M2 positive,of which 97 were men and 148 were women,with the ratio of men to women of about 1∶1.5,and the highest positive rate(28.6%)was found in 46 to 55 year old age group(n=70);serum alkaline phosphatase levels increased in 12 persons with serum AMA-M2 positive,who met the diagnostic criteria of primary biliary cholangitis(PBC);serum ALP level in 54 persons with higher serum AMA-M2(>150U/ml)was(92.8±85.6 U/L),and serum GGT level was(84.3±118.5 U/L,significantly higher than(67.7±38.3U/L)and(39.1±61.8U/L),respectively,P<0.05]in 191 individuals with low serum AMA-M2.Conclusion It is not uncommon that serum AMA-M2 antibody is positive in healthy people,and early screening serum AMA-M2 antibody is helpful for early diagnosis of PBC. |
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| Keywords: | Primary biliary cholangitis Anti-mitochondrial antibody Physical examination and screening Diagnosis |
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