| 云南省布朗族成人非酒精性脂肪性肝病流行特点研究* |
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| 引用本文： | 梁烨倍,杨春光,王昆凤,胡秋明,李妍辉,罗琴,陈浩,郑亚雄,余俊,唐小英,史华祥,牛涛,吴伟,侯旭宏,贾伟平.云南省布朗族成人非酒精性脂肪性肝病流行特点研究*[J].实用肝脏病杂志,2022,25(2):223-226. |
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| 作者姓名： | 梁烨倍 杨春光 王昆凤 胡秋明 李妍辉 罗琴 陈浩 郑亚雄 余俊 唐小英 史华祥 牛涛 吴伟 侯旭宏 贾伟平 |
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| 作者单位： | 200233 上海市 上海交通大学附属第六人民医院内分泌代谢科/上海市糖尿病临床医学中心/上海市糖尿病重点实验室/上海市糖尿病研究所(梁烨倍,杨春光,侯旭宏,贾伟平);云南省西双版纳傣族自治州西双版纳农垦医院医务科(王昆凤);检验科(胡秋明,罗琴,陈浩,郑亚雄,余俊);科教科(李妍辉);医院办公室(吴伟);勐海县布朗山乡卫生院(唐小英);勐海县人民医院医院办公室(史华祥,牛涛) |
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| 基金项目： | 上海市自然科学基金资助项目(编号:18ZR1429000);上海市糖尿病重点实验室开放课题基金资助项目(编号:SHKLD-KF-1602)。 |
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| 摘 要： | 目的 调查云南省勐海县布朗族成人非酒精性脂肪性肝病(NAFLD)的流行特点及其它代谢性疾病的患病情况。方法 2017年2～3月对布朗族聚集且交通便利的5个行政村、18岁及以上3365名居民进行普查,纳入研究3258名。采用问卷调查、体格检查、实验室检测和超声检查。以2010年第六次全国人口普查的人口构成为标准人口构成,计算布朗族成人NAFLD的标化患病率。采用多因素Logistic回归分析NAFLD的患病因素。结果 布朗族成人总体NAFLD标化患病率为16.7%,其中女性患病率为19.9%,显著高于男性的13.6%(x2=4.896,P<0.05);随着年龄的增长,人群和女性NAFLD患病率均呈上升趋势(P趋势<0.001);调整年龄、性别、文化程度、吸烟和饮酒后,多因素Logistic回归分析显示,超重/肥胖(OR:21.6,95% CI 16.8～27.9,P<0.05)、向心性肥胖(OR:14.2,95% CI 10.9～18.6,P<0.05)、高血压(OR:3.7,95% CI 2.8～4.9,P<0.05)、高甘油三酯血症(OR:3.6,95% CI 3.0～4.4,P<0.05)和糖尿病(OR:3.3,95% CI 2.4～4.4,P<0.05)患者患NAFLD的风险均显著高于他们的对照组。结论 布朗族成人有较高的NAFLD患病率,NAFLD与肥胖的关联强度最强,布朗族成人肥胖管理是NAFLD及其它代谢紊乱性疾病管理的关键环节。
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| 关 键 词： | 非酒精性脂肪性肝病 患病率 流行病学调查 布朗族 |
| 收稿时间： | 2021-05-12 |
Epidemiologic investigation of non-alcoholic fatty liver diseases in whole adults of Blang ethnicity in Yunnan province |
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| Liang Yebei,Yang Chunguang,Wang Kunfeng,et al.Epidemiologic investigation of non-alcoholic fatty liver diseases in whole adults of Blang ethnicity in Yunnan province[J].Journal of Clinical Hepatology,2022,25(2):223-226. |
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| Authors: | Liang Yebei Yang Chunguang Wang Kunfeng |
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| Affiliation: | Department of Endocrinology and Metabolism, Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Sixth People's Hospital, Affiliated to JiaoTong University, Shanghai 200233, China |
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| Abstract: | Objective The aim of this study was to investigate the prevalence of non-alcoholic fatty liver diseases(NAFLD)and other metabolic diseases among whole adults of Blang ethnicity in Menghai county in Yunnan province.Methods A cross-sectional study with the census method was performed in this study.All residents of Blang ethnicity aged 18 or over from 5 administrative villages were recruited between February and March 2017.A total of 3365 individuals participated in this survey and eligible 3258 individuals with complete data were included.The data was obtained by questionnaires,physical examinations,blood assays and ultrasonography.The standardized prevalence was adjusted according to the sixth Chinese national census data in 2010.The multivariable Logistic regression was applied to reveal the risk factors for NAFLD.Results The overall standardized prevalence of NAFLD in our series was 16.7%,and of which,the prevalence of NAFLD in women was 19.9%,significantly higher than 13.6%in men(x2=4.896,P<0.05);the prevalence of NAFLD increased as the age increased among the overall population in among women(Ptrend<0.001);the multivariable Logistic regression analysis showed that when the age,gender,education,smoking,and drinking status adjusted,the likelihood of NAFLD in patients with overweight/obesity(OR:21.6,95%CI 16.8-27.9,P<0.05),central obesity(OR:14.2,95%CI 10.9-18.6,P<0.05),hypertension(OR:3.7,95%CI 2.8-4.9,P<0.05),hypertriglyceridemia(OR:3.6,95%CI 3.0-4.4,P<0.05),and diabetes(OR:3.3,95%CI 2.4-4.4,P<0.05)was significantly higher than that in their control group.Conclusion NAFLD is prevalent in Blang ethnic adults and the strongest association is found between obesity and NAFLD.The strict management of weight is a key measure to prevent NAFLD and other metabolic diseases in Blang ethnic adults. |
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| Keywords: | Non-alcoholic fatty liver diseases Prevalence Epidemiologic investigation Blang nationality |
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