| 血糖和总胆固醇水平对肝衰竭患者预后的影响* |
| |
| 引用本文： | 吴凤萍,李亚萍,杨颖,石娟娟,李梅,王文俊,党双锁.血糖和总胆固醇水平对肝衰竭患者预后的影响*[J].实用肝脏病杂志,2018,21(3):413-416. |
| |
| 作者姓名： | 吴凤萍 李亚萍 杨颖 石娟娟 李梅 王文俊 党双锁 |
| |
| 作者单位： | 710004 西安市 西安交通大学医学院第二附属医院感染病科 |
| |
| 基金项目： | * 国家自然科学基金资助项目（编号：81170393） |
| |
| 摘 要： | 目的 分析血糖和总胆固醇（TC）水平对肝衰竭（LF）患者预后的影响。方法 回顾性分析106例LF患者,根据入院时基线TC水平将患者分为TC≤1.0 mmol/L组（n=8）、1.0 mmol/L2.0 mmol/L组（n=49）;排除10例糖尿病患者后,将96例LF患者分为血糖正常组（n=60）、高血糖组（n=12）和低血糖组（n=24）;分别比较基线时患者血糖及TC的状态与其生存率的相关性。同时动态监测81例基线TC>1.0mmol/L的患者住院期间TC的动态变化,分析其与LF预后的关系。结果 106例LF患者的病因以慢性HBV感染为主,占66.0%;慢性肝衰竭(CLF)占46.2%;基线低血糖患者生存率为41.7%,显著低于血糖正常患者的71.7%（P<0.01）;血清TC≤1.0 mmol/L组、1.0 mmol/L2.0 mmol/L患者生存率分别为12.5%、51.0%和75.5%,三组差异有统计学意义,基线TC越低,生存率越低（P均<0.05）;住院期间TC较基线呈下降趋势的35例患者生存率为28.6%,显著低于呈上升趋势的46例患者的93.5% （P<0.05）。结论 LF患者出现血糖降低、TC≤2.0 mmol/L以及在住院期间TC较基线呈下降趋势是预后不良的危险因素,特别是基线TC≤1.0 mmol/L的患者预后极差。
|
| 关 键 词： | 肝衰竭 血糖 总胆固醇 预后 |
| 收稿时间： | 2017-01-19 |
Blood glucose and total cholesterol in the prognosis of patients with liver failure |
| |
| Wu Fengping,Li Yaping,Yang Ying,et al.Blood glucose and total cholesterol in the prognosis of patients with liver failure[J].Journal of Clinical Hepatology,2018,21(3):413-416. |
| |
| Authors: | Wu Fengping Li Yaping Yang Ying |
| |
| Affiliation: | Department of Infectious Diseases,Second Affiliated Hospital,Medical School,Jiaotong University,Xi'an 710004,Shaanxi Province,China |
| |
| Abstract: | Objective To analyze blood glucose and total cholesterol （TC） in the prognosis of patients with liver failure （LF）. Methods A retrospective analysis was performed on 106 LF patients who were admitted to in our hospital. The patients were divided into blood TC≤1.0 mmol/L group（n=8）,1.0 mmol/L2.0 mmol/L group（n=49） according to the TC level at admission. After excluding 10 patients with diabetes,96 patients were divided into normal blood glucose group （n=60）,hyperglycemia group （n=12） and hypoglycemia group（n=24） according to the blood glucose levels at admission. The correlation between blood glucose or TC and survival rate was compared respectively. TC was dynamically monitored in 81 patients with TC>1.0 mmol/L at admission to explore the relationship between the dynamic changes of TC and the prognosis of patients with LF. Results Hepatitis B virus（HBV） infection was the main cause of LF in the 106 patients, accounting for 66.0% and the proportion of chronic liver failure（CLF） accounted for 46.2%;the survival rate in patients with hypoglycemia at admission was 41.7%,significantly lower than that in patients with normal blood glucose （71.7%,P<0.01）;there were significant differences in survival rates between patients with blood TC≤1.0 mmol/L group,1.0 mmol/L2.0 mmol/L group and the lower the baseline TC levels,the lower the survival rates（12.5% vs. 51.0% vs. 75.5%,respectively,P<0.05 for all）;the survival rate in patients with a declining levels of TC during hospitalization was 28.6%,significantly lower than that in patients with an increasing trend （93.5%,P<0.05）. Conclusion Hypoglycemia and blood TC≤2.0 mmol/L at admission or decreased TC level trend are associated with poor prognosis of patients with LF,especially in patients with blood TC≤1.0 mmol/L at admission. |
| |
| Keywords: | Liver failure Blood glucose Total cholesterol Prognosis |
|
| 点击此处可从《实用肝脏病杂志》浏览原始摘要信息 |
|
点击此处可从《实用肝脏病杂志》下载全文 |
|
