| 病毒性心肌炎患者外周血T淋巴细胞亚群及B淋巴细胞的研究 |
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| 引用本文： | 董新,张岩,王聪霞,张春艳,路艳,李永勤,陈俊亮.病毒性心肌炎患者外周血T淋巴细胞亚群及B淋巴细胞的研究[J].心脏杂志,2011,23(1):110-112. |
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| 作者姓名： | 董新 张岩 王聪霞 张春艳 路艳 李永勤 陈俊亮 |
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| 作者单位： | 1.西安交通大学医学院附属第二医院心内科，陕西 西安 710004；2.渭南市人民医院心内科，陕西 渭南 720032 |
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| 摘 要： | 目的: 测定不同时期病毒性心肌炎(VMC)患者T淋巴细胞亚群及B淋巴细胞的数量，并同时检测患者血清心肌损害标志物心肌肌钙蛋白I(cTnI)的水平,探讨其在VMC发病机制中的作用。方法: 采用流式细胞术检测不同时期VMC患者(n=126)外周血CD4+CD45RA+和CD4+CD45RO+以及CD19+的表达,并设正常人群作为对照组(n=50)。结果: 急性期（<3个月）患者CD4+CD45RA+和CD4+CD45RO+以及CD19+与对照组相比差异显著。<1个月以CD4+CD45RA+和CD4+CD45RO+为著（P<0.01；P<0.01）。病程<7 d的患者与对照组相比，CD4+CD45RA+值的降低具有显著性(P<0.01)；CD4+CD45RO+值下降明显(P<0.01)。而病程7~14 d、14~21 d及21~30 d的患者CD4+CD45RA+值、CD4+CD45RO+值及CD19+值与对照组相比差异均有统计学意义，CD4+CD45RO+值恢复较快。CD4+CD45RA+/CD4+CD45RO+在发病14 d内的患者与对照组差异无统计学意义；而14~30 d的患者与对照组相比差异有显著性。发病1~3个月患者以CD19+为著（P<0.01）。急性期CD4+CD45RA+/CD4+CD45RO+细胞的比例失衡。恢复期（3~12个月）患者CD4+CD45RA+和CD4+CD45RO+以及CD19+、CD4+CD45RA+/CD4+CD45RO+细胞的比例与对照组相比差异无显著性。结论: VMC患者感染初期（<1个月）以T淋巴细胞亚群异常为主，感染后期（1~3个月）以B淋巴细胞异常较为显著，以上两时期均存在CD4+CD45RA+/ CD4+CD45RO+细胞比例失衡。恢复期（3~12个月）T淋巴细胞及B淋巴细胞逐渐恢复至正常。
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| 关 键 词： | 病毒性心肌炎 T淋巴细胞亚群 B细胞 流式细胞术 |
| 收稿时间： | 2009-03-23 |
Role of T lymphocyte subgroup and B lymphocytes in viral myocarditis |
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| DONG Xin,ZHANG Yan,WANG Cong-xia,ZHANG Chun-yan,LU Yan,LI Yong-qin,CHEN Jun-liang.Role of T lymphocyte subgroup and B lymphocytes in viral myocarditis[J].Chinese Heart Journal,2011,23(1):110-112. |
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| Authors: | DONG Xin ZHANG Yan WANG Cong-xia ZHANG Chun-yan LU Yan LI Yong-qin CHEN Jun-liang |
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| Affiliation: | DONG Xin,ZHANG Yan,WANG Cong-xia,ZHANG Chun-yan,LU Yan,LI Yong-qin,CHEN Jun-liang (Department of Cardiology,Second Hospital,School of Medicine,Xi'an Jiaotong University,Xi'an 710004,Shaanxi,China) |
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| Abstract: | AIM: To explore the role of T lymphocyte subgroup and B lymphocytes in the pathogenesis of viral myocarditis.METHODS: The quantity of CD4+CD45RA+,CD4+CD45RO+ and CD19+ in peripheral blood of viral myocarditis patients was detected using flow cytometry,and cTnI level was measured.Healthy subjects served as controls.RESULTS: The quantity of CD4+CD45RA+,CD4+CD45RO+ and CD19+ in acute patients(<1 month) was significantly different from those in controls(P<0.05).The difference of CD4+CD45RA+ and CD4+CD45RO+ was ... |
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| Keywords: | T lymphocyte subgroup B lymphocyte viral myocarditis flow cytometry |
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