Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. |
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| Authors: | N Y Ip C F Ibá?ez S H Nye J McClain P F Jones D R Gies L Belluscio M M Le Beau R Espinosa rd S P Squinto |
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| Affiliation: | Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591. |
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| Abstract: | Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) are the three members of the neurotrophin family known to exist in mammals. Recently, a fourth neurotrophin (designated neurotrophin-4 or NT-4), which shares all of the features found in the mammalian neurotrophins, has been identified in Xenopus and viper. We used sequences specific to the Xenopus/viper NT-4 to isolate a neurotrophin from both human and rat genomic DNA that appears to represent the mammalian counterpart of Xenopus/viper NT-4. Human NT-4 as well as a human NT-4 pseudogene colocalize to chromosome 19 band q13.3. Mammalian NT-4 has many unusual features compared to the previously identified neurotrophins and is less conserved evolutionarily than the other neurotrophins. However, mammalian NT-4 displays bioactivity and trk receptor specificity similar to that of Xenopus NT-4. |
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