| 胆石病家族聚集性及遗传方式的研究 |
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| 引用本文： | 杨松,谈永飞,喻荣彬,彭俊,沈靖,姚才良.胆石病家族聚集性及遗传方式的研究[J].中华流行病学杂志,1999,20(5). |
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| 作者姓名： | 杨松 谈永飞 喻荣彬 彭俊 沈靖 姚才良 |
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| 作者单位： | 1. 214200,江苏省宜兴市人民医院
2. 南京医科大学公共卫生学院 |
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| 摘 要： | 目的 探索胆石病家族聚集性及遗传方式。方法 采用遗传流行病学病例对照研究方法 ,对 317个家系 ( 138个胆石病先证家系和 179个对照家系 )进行研究。结果 病例组一级亲属总的胆石病患病率为 2 .60 % ,显著高于对照组的 1.2 9% ( χ2 =4.78,P =0 .0 2 88) ;分离比为显著低于 0 .2 5 ,不符合单基因遗传疾病的特征 ;遗传度估算显示 ,该病一级亲属中 ,遗传度为2 1.80 % ,其中男性亲属的遗传度为 36.34% ,显著高于女性亲属的 14 .15 %。结论 在胆石病的病因中 ,遗传因素起一定作用 ,尤其对男性作用更为明显。
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| 关 键 词： | 胆石病 遗传方式 遗传度 |
A study on the genetic epidemiology of gallstone disease |
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| YANG Song,TAN Yongfei,YU Rongbin,et al..A study on the genetic epidemiology of gallstone disease[J].Chinese Journal of Epidemiology,1999,20(5). |
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| Authors: | YANG Song TAN Yongfei YU Rongbin |
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| Affiliation: | YANG Song,TAN Yongfei,YU Rongbin,et al. Yixin People's Hospital of Jiangsu Province,Yixin 214200 |
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| Abstract: | Objective To explore the genetic model of gallstone disease (GD). Methods A case- control study including 317 pedigrees (138 cases and 179 controls) was conducted. Results The prevelence of the first-degree relatives in cases was 2.60 %, significantly higher than that noticed in controls ( 1.29 %). Segregation analysis showed that GD did not possess the characteristics of monogenic model. Meanwhile the results showed that the heritability of the first-degree relatives was 21.80 %,with male 36.34 % which was significantly higher than the females ( 14.15 %). Conclusion This study indicated that the genetic factors played an important role in the occurrence of GD, especially in males. |
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| Keywords: | Gallstone disease Genetic model Heritability |
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