| 2011 - 2018年武汉市手足口病流行病学与病原学特征分析 |
| |
| 引用本文： | 孔德广,庞蓓蓓,鲁莎,彭颖,杨小兵.2011 - 2018年武汉市手足口病流行病学与病原学特征分析[J].现代预防医学,2020,0(2):223-227. |
| |
| 作者姓名： | 孔德广 庞蓓蓓 鲁莎 彭颖 杨小兵 |
| |
| 作者单位： | 1.武汉市疾病预防控制中心传染病防制所，湖北 武汉430023；2.武汉市疾病预防控制中心病原检测所，湖北 武汉430023 |
| |
| 摘 要： | 目的 回顾性分析武汉市2011 - 2018年手足口病（hand，foot，and mouth disease，HFMD）流行病学与病原学特征，为HFMD的防控策略提供决策依据。方法 从《中国疾病预防控制信息系统》中导出武汉市2011 - 2018年HFMD疫情资料，整理其标本登记信息和病原学检测结果；采用卡方检验比较采集病例标本时间与病原学检测结果的差异性，运用SPSS 22.0软件开展统计学分析。结果 武汉市2011 - 2018年累计报告HFMD 121 147例，年均发病率为148.23/10万，2016年处于历年报告发病的最高水平，整体报告发病率呈现逐年上升的趋势。重症114例，死亡1例。HFMD流行表现出两个高峰，4 - 7月为春夏季高峰，10 - 12月秋冬季为次高峰。男女性别比为1.56∶1，5岁及以下儿童占95.81%（116 066/121 147），发病以散居儿童为主（占56.40%，68 328/121 147）。普通病例中EV71构成呈下降趋势，其它肠道病毒构成呈上升趋势，CVA16构成呈周期性的波动；重症病例中检出的EV71占80.70%（92/114）。普通病例中病原检出率为73.60%（4 645/6 311），不同采集标本时间的检出率差异具有统计学意义（χ2 = 165.268，P＜0.001）。结论 武汉市HFMD发病率总体呈上升趋势，表现出隔年高发和季节性高峰，5岁及下儿童是重点人群。重症病例仍以EV71为主；普通病例中的优势病原转变为其它肠道病毒和CVA16为主，应进一步加强病原谱的监测。病原学监测工作应尽早采集病例标本送检。
|
| 关 键 词： | 手足口病 流行病学 病原学 柯萨奇病毒 肠道病毒 |
Analysis on epidemiologic and etiologic characteristics of hand-foot-and-mouth disease in Wuhan between 2011 and 2018 |
| |
| KONG De-guang,PANG Bei-bei,LU Sha,PENG Ying,YANG Xiao-bing.Analysis on epidemiologic and etiologic characteristics of hand-foot-and-mouth disease in Wuhan between 2011 and 2018[J].Modern Preventive Medicine,2020,0(2):223-227. |
| |
| Authors: | KONG De-guang PANG Bei-bei LU Sha PENG Ying YANG Xiao-bing |
| |
| Affiliation: | *Wuhan Center for Disease Control and Prevention, Wuhan, Hubei 430023, China |
| |
| Abstract: | Objective To retrospectively analyze the epidemiological and etiologic characteristics of hand-foot-and-mouth disease(HFMD) in Wuhan from 2011 to 2018, so as to provide decision-making basis for prevention and control of HFMD.Methods The data of HFMD were derived from China Information System for Disease Control and Prevention, and the registration information of HFMD specimens and the results of pathogen detection were sorted out from 2011 to 2018. Chisquare test was used to compare the difference between time of collecting specimens and results of pathogen detection, and statistical analysis was carried out by SPSS 22.0 software. Results Total of 121147 cases of HFMD were reported, with average annual incidence of 148.23/100000. The overall incidence rate of HFMD showed upward trend, which was at the highest level in 2016. 114 severe cases and one death appeared in Wuhan, from 2011 to 2018. There were two peeks of HFMD incidence,the main peak was in spring and summer from April to July, and the secondary peak was in autumn and winter from October to December. The ratio of male to female was 1.56:1. 95.81 percent(116066/121147) of patients were children under 5 years old,and the number of cases and incidence rate of 1-3 years old children were the highest. The majority of patients were scattered children(56.40%, 68328/121147). EV71 showed a downward trend, while other enterovirus had an upward trend and CVA16 fluctuated periodically in mild cases, and EV71 was detected with 80.70%(92/114) in severe cases. The detection rate of pathogen was 73.60%(4645/6310) in mild cases, and the difference was statistically significant between positive rate and sampling time(χ2=165.268, P<0.001). Conclusion The overall incidence of HFMD showed an upward trend; biennial epidemic and peaks seasonally, children aged 5 years and younger were the key population infected with HFMD. The pathogen of severe patients was still dominated by EV71, while changing to other enterovirus and CVA16 mild cases. Therefore, the surveillance of pathogen spectrum should be strengthened. Specimens should be collected and transferred to the laboratory early in pathogen surveillance of HFMD. |
| |
| Keywords: | Hand-foot-and-mouth disease Epidemiology Pathogen Coxsackie virus Enterovirus |
|
| 点击此处可从《现代预防医学》浏览原始摘要信息 |
|
点击此处可从《现代预防医学》下载全文 |
|
