| 全球SARS-CoV-2再次感染率的Meta分析 |
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| 引用本文： | 马一瑞,邓洁,梁万年,刘民,刘珏.全球SARS-CoV-2再次感染率的Meta分析[J].中华疾病控制杂志,2023,27(2):127-135. |
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| 作者姓名： | 马一瑞 邓洁 梁万年 刘民 刘珏 |
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| 作者单位： | 1.100191 北京，北京大学公共卫生学院流行病与卫生统计学系 |
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| 基金项目： | 国家自然科学基金72122001国家自然科学基金72211540398国家自然科学基金71934002北京市自然科学基金-海淀原始创新联合基金L222027 |
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| 摘 要： | 目的 系统评估SARS-CoV-2再次感染率，为减少SARS-CoV-2再次感染的发生提供循证依据。 方法 检索PubMed、Embase、Web of Science、中国知网和万方等电子数据库自建库至2022年12月11日与SARS-CoV-2再次感染相关的队列研究或病例对照研究，按照严格的纳入排除标准筛选文献、提取数据并进行质量评价，采用Stata 16.0统计软件进行统计分析。 结果 共纳入24篇文献，包含初次感染患者6 616 869例、再次感染者78 635例。初次感染者的再次感染率为2.06%(95% CI: 1.73%~2.40%)。相比于其他年龄组，40岁以上中年人的再次感染率更高，40~＜50岁人群为2.97%(95% CI: -1.20%~7.14%)，50~＜60岁人群为2.32%(95% CI: -0.74%~5.38%)。相比于接种新型冠状病毒疫苗(简称新冠疫苗)人群，未完全接种组的再次感染率为1.85%(95% CI: 1.63%~2.08%)，完全接种组的再次感染率为1.11%(95% CI: 0.34%~1.89%)，未接种疫苗人群的再次感染率更高为5.47%(95% CI: 1.99%~8.95%)。医护人员的再次感染率为6.02%(95% CI: 5.67%~6.37%)。 结论 SARS-CoV-2存在再次感染的风险，但本研究结果表明再次感染的比例不高。建议科学认识SARS-CoV-2的再次感染风险，加强公众健康宣教，保持健康习惯，减少再次感染风险。
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| 关 键 词： | 新型冠状病毒 再次感染 Meta分析 |
| 收稿时间： | 2022-12-30 |
Meta-analysis of SARS-CoV-2 reinfection rate in the world |
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| Affiliation: | 1.Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China2.Vanke School of Public Health, Tsinghua University, Institute for Health China, Tsinghua University, Beijing 100084, China |
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| Abstract: | Objective We aimed to review the data available to explore prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection in the real world. Methods We searched observational cohort studies and case-control studies that described the SARS-CoV-2 reinfections in PubMed, Embase, Web of Science, CNKI and WanFang Data from inception to 11 Dec 2022. Studies, data extracted and quality assessed were selected according to strict inclusion exclusion criteria. All analyses were using Stata version 16.0. Results A total of 24 studies were included, involving 78 635 cases of SARS-CoV-2 reinfection and 6 616 869 cases of SARS-CoV-2 primary infection. In cases after the primary SARS-CoV-2 infection, the pooled prevalence of reinfection was 2.06% (95% CI: 1.73%-2.40%). Compared with other age groups, the secondary infection rate was higher in those aged 40- < 50 years 2.97% (95% CI: -1.20%-7.14%) and 50- < 60 years 2.32% (95% CI: -0.74%-5.38%). In vaccination status group, the pooled prevalence was 5.47% (95% CI: 1.99%-8.95%) in unvaccinated cases, 1.85% (95% CI: 1.63%-2.08%) for those received partial COVID-19 vaccination, and 1.11%(95% CI: 0.34%-1.89%) for those received fully vaccination. In addition, the pooled prevalence of SARS-CoV-2 reinfection was 6.02%(95% CI: 5.67%-6.37%) in the health care workers. Conclusions There is a risk of SARS-CoV-2 reinfection, but the results of this global real-world meta-analysis showed that the rate of reinfection is not high. It is recommended to scientifically understand the risk of SARS-CoV-2 reinfection, strengthen public health education, maintain healthy habits, and reduce the risk of SARS-CoV-2 reinfection. |
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