| Nogo基因多态性与鼻咽癌相关性的病例对照研究 |
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| 引用本文： | 王荣,覃海媚,庞晓霞,杨凤莲,韦玉霞,张婷,韦叶生,王俊利.Nogo基因多态性与鼻咽癌相关性的病例对照研究[J].中华疾病控制杂志,2018,22(8):772. |
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| 作者姓名： | 王荣 覃海媚 庞晓霞 杨凤莲 韦玉霞 张婷 韦叶生 王俊利 |
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| 作者单位： | 1. 右江民族医学院临床检验诊断学系, 广西 百色 533000; |
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| 基金项目： | 国家自然科学基金（81560461） |
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| 摘 要： | 目的 探讨Nogo基因rs2255393和rs968998多态性与鼻咽癌（nasopharyngeal carcinoma，NPC）易感性关系。方法 SNaPshot技术和DNA测序法检测276例NPC患者与276例健康对照者的rs2255393和rs968998基因型。用统计学分析两组基因型、等位基因与NPC易感性的关系。结果 rs968998位点基因型及等位基因在两组中比较差异均无统计学意义（均有P>0.05）。但rs2255393位点TT基因型（OR=0.58，95% CI:0.34~0.97，P=0.039）和显性模型（AA+TA）（OR=0.62，95% CI:0.44~0.87，P=0.006）在NPC组和对照组中的分布差异有统计学意义。此外，T等位基因在NPC组的频率低于对照组，分布差异也有统计学意义（OR=0.72，95% CI:0.56~0.92，P=0.009）。而rs2255393多态性和NPC患者临床分期，淋巴转移和远处转移比较，差异均无统计学意义（均有P>0.05）。结论 Nogo基因rs2255393位点多态性与NPC发病风险存在关联，但与临床肿瘤分期无关。
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| 关 键 词： | 鼻咽癌 Nogo 多态性 病例对照研究 |
| 收稿时间： | 2018-02-07 |
Association between genetic polymorphisms in Nogo gene and the susceptibility of nasopharyngeal carcinoma: a case-control study |
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| Affiliation: | 1. Department of Clinical Laboratory Diagnostics, Youjiang Medical University for Nationalities, Baise 533000, China;2. Department of Laboratory Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China;3. Laboratory of Reproductive Genetic, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China |
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| Abstract: | Objective To investigate the association of the genetic polymorphisms rs2255393 and rs968998 in Nogo gene with the susceptibility of nasopharyngeal carcinoma (NPC). Methods SNaPshot and DNA sequencing were used to screen the genotypes of rs2255393 and rs968998 in 276 NPC patients and 276 healthy volunteers. The comparison of distribution differences of genotype and allele frequencies was performed using statistical methods in disease and control groups. Results The difference of genotype and allele frequencies in rs968998 between NPC patients and controls had no statistical significance (all P>0.05). However, the difference between TT genotype (OR=0.58, 95% CI:0.34-0.97, P=0.039) and dominant model (AA+TA) of rs2255393 (OR=0.62, 95% CI:0.44-0.87, P=0.006) was statistically significant in NPC patients and controls. Moreover, The frequencies of its T allele in NPC patients was lower than those in controls, and the distribution difference was statistically significant (OR=0.72, 95% CI:0.56-0.92, P=0.009). There was no statistically significant difference between rs2255393 polymorphism and NPC pathological features (clinical staging, lymphatic metastasis and distant metastasis) (all P>0.05). Conclusions The genetic polymorphism rs2255393 of Nogo gene is associated with the risk of nasopharyngeal carcinoma, but is not correlated with clinical tumor staging. |
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