| 乌鲁木齐市某区全民体检人群代谢综合征组分聚集性与非酒精性脂肪肝关系 |
| |
| 引用本文： | 古丽斯亚·海力力,姚华,王淑霞,王育珊,刘涛,陈珍,罗涛,戴江红.乌鲁木齐市某区全民体检人群代谢综合征组分聚集性与非酒精性脂肪肝关系[J].中华疾病控制杂志,2019,23(11):1358-1363. |
| |
| 作者姓名： | 古丽斯亚·海力力 姚华 王淑霞 王育珊 刘涛 陈珍 罗涛 戴江红 |
| |
| 作者单位： | 新疆医科大学公共卫生学院,乌鲁木齐,830011;新疆医科大学第一附属医院健康管理中心,乌鲁木齐,830000 |
| |
| 基金项目： | 国家重点研发计划项目:新疆多民族自然人群队列建设及健康随访研究2017YFC0907203新疆维吾尔自治区自然科学基金项目2017D01C425 |
| |
| 摘 要： | 目的 通过代谢综合症评分（metabolic syndrome score，MSS）反映代谢综合症（metabolic syndrome，MetS）组分聚集性，探讨乌鲁木齐市（乌市）MetS、MSS与非酒精性脂肪性肝病（nonalcoholic fatty liver disease，NAFLD）关系。 方法 通过腹部B超分无NAFLD和NAFLD组，分析两组人群体格、血生化检查结果，计算MSS，采用Log-binomial回归分析模型分析MSS不同聚集性与NAFLD的关系。 结果 共纳入研究对象20 569例，MetS检出率为16.7，NAFLD检出率为32.4%，与NAFLD组比较，NAFLD组收缩压、舒张压、体质指数（body mass index，BMI）、腰围、空腹血糖、甘油三酯、胆固醇、低密度脂蛋白胆固醇均升高，差异均有统计学意义（P < 0.05）；调整性别、年龄、民族、文化程度后，Log-binomial回归分析模型结果显示，高BMI、高血压、高血糖、高甘油三酯和低高密度脂蛋白是NAFLD主要危险因素（PR值分别为3.194、1.331、1.623、1.981、1.254）；NAFLD的风险随MSS增加而增加，MSS0、MSS1、MSS2、MSS3和MSS4的PR值分别为3.127、4.983、6.437、7.331。 结论 NAFLD的形成不是单一的肝脏脂肪堆积，而合并有血脂、血压、血糖等异常。男性MetS和NAFLD检出率高于女性，但两个代谢指标异常的女性更有可能发展成为NAFLD。BMI作为肥胖指标与NAFLD关系最强，NAFLD防治应重点关注肥胖人群。
|
| 关 键 词： | 代谢综合症 代谢综合症评分 非酒精性脂肪肝 |
| 收稿时间： | 2019-07-07 |
Correlation between metabolic syndrome component aggregation and nonalcoholic fatty liver disease in a certain district of Urumqi's check-up population |
| |
| Affiliation: | 1.School of Public Health, Xinjiang Medical University, 830011, Urumqi, China2.Health Management Center, the First Affiliated Hospital of Xinjiang Medical University, 830000, Urumqi, China |
| |
| Abstract: | Objective The relationship between metabolic syndrome(MetS), metabolic syndrome score (MSS) and non-alcoholic fatty liver disease(NAFLD) in Urumqi was investigated by the MSS, reflecting the aggregation of MetS components. Methods The subjects were divided into non-NAFLD and NAFLD group by abdominal B ultrasound. The results of physical examination and blood biochemical examination were analyzed. The MSS was calculated and the relationship between the different aggregation of MSS and NAFLD was analyzed by Log-binomial regression. Results A total of 20 569 subjects were included in the study. The detection rate of MetS was 16.7%, the detection rate of NAFLD was 32.4%. Compared with non-NAFLD group, the systolic blood pressure, diastolic blood pressure, body mass index (BMI), waist circumference, fasting plasma glucose, triglyceride, total cholesterol, and low-density lipoprotein cholesterol were all increased in the NAFLD group, and the difference was statistically significant (P < 0.05). After adjusting for gender, age, ethnicity and education level, Log-binomial regression analysis showed high BMI, hypertension and hyperglycemia. High triglycerides and low-density lipoproteins are the main risk factors for NAFLD (PR values were 3.194, 1.331, 1.623, 1.981, 1.254, respectively); the risk of NAFLD increased corresondingly when MSS, MSS0, MSS1, MSS2, MSS3, and MSS4 increased. The PR were 3.127, 4.983, 6.437, and 7.331, respectively. Conclusions The formation of NAFLD is not a single accumulation of liver fat, combined with abnormalities such as blood lipids, blood pressure, and blood sugar. The detection rate of male MetS and NAFLD was higher than that of female, but women with two abnormal metabolic indicators were more likely to develop into NAFLD. BMI as the obesity index has the strongest relationship with NAFLD, and NAFLD prevention should focus on obese people. |
| |
| Keywords: | |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《中华疾病控制杂志》浏览原始摘要信息 |
|
点击此处可从《中华疾病控制杂志》下载全文 |
|
