| 贵州省成人流行性乙型脑炎病毒中和抗体水平调查 |
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| 引用本文： | 赵苏晔,刘淳婷,王宇,刘铭,蒋维佳,郭华.贵州省成人流行性乙型脑炎病毒中和抗体水平调查[J].中华疾病控制杂志,2019,23(2):241-244. |
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| 作者姓名： | 赵苏晔 刘淳婷 王宇 刘铭 蒋维佳 郭华 |
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| 作者单位： | 550004,贵州省疾病预防控制中心;550004,贵州省疾病预防控制中心;550004,贵州省疾病预防控制中心;550004,贵州省疾病预防控制中心;550004,贵州省疾病预防控制中心;550004,贵州省疾病预防控制中心 |
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| 基金项目： | 贵州省卫生计生委科学技术基金项目gzwjkj2017-1-051贵州省疾病预防控制中心科技基金2017-E1-2 |
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| 摘 要： | 目的 调查贵州省成人流行性乙型脑炎（乙脑）病毒中和抗体水平。 方法 采用多阶段随机抽样的方法，在2017年5~6月采集3个市（州）6个年龄组健康成人血清共360份，应用蚀斑减少中和试验法检测乙脑病毒中和抗体。 结果 360名调查对象中乙脑病毒中和抗体阳性率为55.28%，几何平均滴度（GMT）为1 ∶17.52。不同性别（χ2=10.798，P=0.001）、不同发病率地区（χ2=6.090，P=0.048）成人乙脑病毒中和抗体阳性率差异具有统计学意义（均有P<0.05）；不同年龄成人乙脑病毒中和抗体阳性率在45.00%~60.00%之间（χ2=4.236，P=0.516）；不同民族中，布依族成人乙脑病毒中和抗体阳性率最高（79.17%）。 结论 贵州省成人乙脑病毒中和抗体水平较低，存在成人乙脑流行风险。
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| 关 键 词： | 流行性乙型脑炎 成人 中和抗体 蚀斑减少中和试验 |
| 收稿时间： | 2018-05-16 |
Investigation on neutralizing antibody level of Japanese encephalitis virus in adults from Guizhou Province |
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| Affiliation: | Guizhou Provincial Center for Disease Control and Prevention, Guiyang 550004, China |
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| Abstract: | Objective To investigate the level of neutralizing antibodies against Japanese encephalitis (JE) virus in adults from Guizhou Province. Methods A multi-stage random sampling method was used to collect 360 serum of healthy adults in 6 age groups of 3 cities (states) from May to June 2017. Neutralizing antibodies against Japanese encephalitis virus of healthy adults were detected by plaque reduction neutralization test. Results The positive rate of neutralizing antibodies against Japanese encephalitis virus was 55.28%, and the geometric mean titer (GMT) was 1:17.52 in 360 subjects. The difference of the positive rates of neutralizing antibodies against Japanese encephalitis virus of adults in different genders (χ2=10.798, P=0.001) and in different incidence regions(χ2=6.090, P=0.048)was statistically significant(both P<0.05). The positive rate of different age groups was 45.00%-60.00% (χ2=4.236, P=0.516). The positive rate of Buyi nationality was the highest (79.17%). Conclusions The level of neutralizing antibodies against Japanese encephalitis virus of adults in Guizhou province is low, and there is a risk of epidemic encephalitis in adults. |
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