| 妇女孕期磷肥暴露与早产发生风险的关联 |
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| 引用本文： | 张远,李佳佳,林是琦,武继磊,裴丽君.妇女孕期磷肥暴露与早产发生风险的关联[J].中华疾病控制杂志,2021,25(10):1214-1219. |
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| 作者姓名： | 张远 李佳佳 林是琦 武继磊 裴丽君 |
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| 作者单位： | 1.100871 北京，北京大学人口研究所，北京大学人口健康与发展研究中心 |
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| 基金项目： | 国家重点研发计划2018YFC1004303国家自然科学基金41871360河南省卫生健康委员会出生缺陷预防重点实验室开放课题ZD202002 |
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| 摘 要： | 目的 了解农村化肥施用量与早产发生风险的关系，为提高出生人口素质提供参考。 方法 利用山西省平定县2007年10月1日至2012年9月30日的出生人口监测数据，随访获得155例早产新生儿，从同时期出生、无任何体表缺陷、孕周≥37周、正常出生体重(2 500~4 000 g)的新生儿中，随机选择204例作为对照组。采用分层多因素Logistic回归分析模型和结构方程模型分析方法，探索早产发生风险与母亲孕期化肥暴露之间的关联及多种暴露因素对早产风险的贡献。 结果 分层多因素Logistic回归分析模型结果显示，调整混杂因素后，暴露于村级化肥施用量≥100 t的妇女早产发生风险大于村级化肥施用量＜50 t的妇女(aOR=2.51, 95% CI:1.23~5.12)；妇女家庭施用磷肥是早产发生的危险因素(aOR=2.54, 95% CI:1.23~5.22)；结构方程模型检验发现，村级化肥施用量是对妇女早产发生风险贡献较大的环境因素。 结论 妇女孕期暴露于化肥，特别是磷肥与早产发生风险存在关联，建议农村妇女孕期尽量避免暴露于化肥施用环境。
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| 关 键 词： | 早产 化肥 磷肥 孕期 妇女 关联 |
| 收稿时间： | 2020-10-24 |
Association between maternal exposure to phosphate fertilizers during pregnancy and the risk of preterm birth |
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| Affiliation: | 1.Institute of Population Research, Peking University, Center for Population Health and Development, Peking University, Beijing 100871, China2.National Research Institute for Health and Family Planning, Beijing 100081, China |
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| Abstract: | Objective To explore the association between consumption of chemical fertilizers and the risk of preterm birth, to provide references for improvement of birth outcomes. Methods Using the birth population monitoring data from October 1, 2007 to September 30, 2012 in Pingding County, Shanxi Province, 155 cases of preterm birth were followed up, and 204 newborns with normal birth weight (2 500~4 000 g) born at the same time without any surface defects and gestational age ≥37 weeks were randomly selected as the control group. Stratified multivariate Logistic regression model and structural equation model were used to investigate the associations between the risk of preterm birth and maternal exposure to chemical fertilizers during pregnancy. Results The results of the stratified multivariate Logistic regression analysis model showed that after adjusting for confounding factors, women exposed to village-level fertilizer application ≥100 t had a higher risk of preterm birth than women who had village-level fertilizer application < 50 t (aOR=2.51, 95% CI: 1.23-5.12). Household consumption of phosphorus fertilizer was a risk factor for premature birth (aOR=2.54, 95% CI: 1.23-5.22). The findings of structural equation model indicated that maternal exposure to phosphate fertilizer during pregnancy may be an important environmental factor for the risk of premature birth. Conclusions Women's exposure to chemical fertilizers during pregnancy, especially phosphate fertilizers, is associated with the risk of preterm birth, so it is recommended that rural women should try to avoid exposure to chemical fertilizers during pregnancy. |
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