| 雾化吸入粒细胞-巨噬细胞集落刺激因子治疗肺转移癌的临床研究 |
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| 引用本文： | 吴登斌,王文萍,高晶晶,王忠帅,艾春玲,高广营.雾化吸入粒细胞-巨噬细胞集落刺激因子治疗肺转移癌的临床研究[J].肿瘤研究与临床,2009,21(6):608-610,613. |
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| 作者姓名： | 吴登斌 王文萍 高晶晶 王忠帅 艾春玲 高广营 |
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| 作者单位： | 110032,沈阳,辽宁中医药大学附属医院临床药品试验基地;鞍山曙光医院肿瘤放疗科;辽宁中医药大学附属医院临床药品试验基地,沈阳,110032;鞍山曙光医院肿瘤放疗科; |
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| 摘 要： | Objective To evaluate the feasibility of granulocyte macrophage-colony stimulating factor (GM-CSF)delivery to the lung using an aerosol in patients with metastatic lung cancer to the lungs.Methods A Phase I dose escalation study inhaled GM-CSF at three dose levels as twice-a-dayx7 days schedule.Blood counts were checked at the beginning and end of each week of GM-CSF nebulization. If no toxicity was encountered,in-patients rested for 7 days and then were inhaled at the next dose level.Results Six of sevenpatients were all dose escalated from 60 μg/dose twice-a-dayx7 days,to 120μ g/dose twice-a-dayx7 days,then 240μg/dose twice-a-dayx7 days,one of the patients with cerebral hemorrhage was removed from the clinical trials,and no toxicity was seen.Comparison of inhaled GM-CSF of day 0 and day 7 blood leukocyte counts and percentage of neutrophils,it showed no significant difference in analysis of blood count data at the beginning and end of nebulization used paired t tests for each dose level.The other 9 patients received an additional 2-6 months of intermittent aerosol GM-CSF at 240 μg dose level without side effect.Two patients with bilateral lung metastases of lung adenocarcinoma had a progress disease after 2-2.5 months of aerosol GM-CSF.One patient with lung metastasis of SCLC had a progressive disease after 2 months of aerosol GM-CSF,the other 6 patients had stabilization of pulmonary metastases for 2-6 months. Conclusion Aerosol delivery of GM-CSF may achieve effective immunological antitumor action in the metastases tumor to lungs,and this therapy is feasible and possibly effective and worthy of further study.
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| 关 键 词： | 粒细胞巨噬细胞集落刺激因子 肺肿瘤 肿瘤转移 投药 吸入 |
Clinical study of inhaled GM-CSF for patients with metastatic lung cancer to the lungs |
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| Keywords: | Granulocyte-macrophage colony-stimulating factorLung neoplasmsNeoplasm metastasisAdministrationinhalation |
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