| 伴NPM1基因突变的成年人急性髓系白血病临床研究 |
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| 引用本文： | 孙明东,王国卿,李尊昌,韩风霞,丁梅,王雨存,杨胜,赵海涛,王占聚.伴NPM1基因突变的成年人急性髓系白血病临床研究[J].白血病．淋巴瘤,2010,20(11):232-235. |
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| 作者姓名： | 孙明东 王国卿 李尊昌 韩风霞 丁梅 王雨存 杨胜 赵海涛 王占聚 |
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| 作者单位： | 山东省滨州市人民医院血液科,256610;山东省滨州市人民医院神经科,256610;潍坊医学院附属医院血液科; |
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| 摘 要： | Objective To evaluate the clinical feature of adult acute myeloid leukemia with nucleophosmin (NPM1) cytoplastic positive (NPMc+AML), and to investigate the significance of the NPM1 gene mutations regularly in detecting the early relapse. Methods The NPM1 gene mutations was screened by the PCR-capillary electrophoresis in 95 newly diagnosed adult AML patients. 5 complete remission AML patients were selected to detecte the NPM1 gene mutations regularly. Results In 95 cases of adult AML patients, the incidence of the NPM1 mutations was 9.5 % (28/95). The incidence of the NPM1 mutations in patients (≥40-year-old) was higher clearly than it' s in pazients (40-year-old) (λ 2= 6.963, P = 0.012). That in the AML patients with normal karyotype (51.1%) was higher than that in the patients with abnormal karyotype (8.3 %) (λ2= 20.860, P= 0.0000). NPM1 mutations occured with a considerate percentage in AML patients with M5/M2 subtype. In AML with recurrent genetic abnormalities the NPM1 mutations wasn' t found.The white blood cell count, platelet count, lactate dehydrogenase in the NPMc+AML patients were clearly higher than that in the NPMc-AML patients (t were individually 4.132, 4.603, 4.069, P ＜0.05). The rate of complete remission, relapse-free survival and overall survival in the NPMc+AML patients were also higher than that in the N PMc-AML patients (λ 2 were individually 10.448, 4.146, 4.384, P ＜0.05). In cases detected regularly NPM1 mutations preceded the hematological relapse about 1.5-2 months. Conclusion NPM1 gene mutations has a higher incidence in adult AML, particularly in normal karyotype AML. The clinical manifestations are older, and higher in white blood cell count, platelet count, and lactate dehydrogenase. The NPM1 mutations in adult AML is a good factor for prognosis. The regular detection of NPM1 mutation could find relapse early.
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| 关 键 词： | 白血病 髓样 急性 突变 NPM1基因 |
Clinical study of adult acute myeloid leukemia with nucleophosmin cytoplastic positive |
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| SUN Ming-dong,WANG Guo-qing,LI Zun-chang,HAN Feng-xia,DING Mei,WANG Yu-cun,YANG Sheng,ZHAO Hai-tao,WANG Zhan-ju.Clinical study of adult acute myeloid leukemia with nucleophosmin cytoplastic positive[J].Journal of Leukemia & Lymphoma,2010,20(11):232-235. |
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| Authors: | SUN Ming-dong WANG Guo-qing LI Zun-chang HAN Feng-xia DING Mei WANG Yu-cun YANG Sheng ZHAO Hai-tao WANG Zhan-ju |
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| Abstract: | |
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| Keywords: | Leukemia myeloid chronicMutationNPM1 gene |
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