| 骨肉瘤与Wnt信号传导通路的研究进展 |
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| 引用本文： | 魏天犁综述,曲国蕃审校.骨肉瘤与Wnt信号传导通路的研究进展[J].实用肿瘤学杂志,2013,27(4):363-366. |
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| 作者姓名： | 魏天犁综述 曲国蕃审校 |
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| 作者单位： | 哈尔滨医科大学附属肿瘤医院骨外科(哈尔滨 150081) |
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| 摘 要： | 骨肉瘤是青少年及儿童最常见的原发性恶性骨肿瘤, 40%的患者预后不佳。有研究发现, Wnt信号传导通路在骨细胞的增殖、分化和凋亡中起重要作用。这条通路在骨量的调节过程中有着关键性的意义。其通过一系列调控蛋白进行功能调节。通路调控异常引发其组成成分的突变, 导致了一系列骨疾病, 特别是骨肉瘤的发生。Wnt信号通路相关靶向治疗药物的应用, 可以使骨肉瘤的治疗得到更好的发展, 并且这类药物已逐渐受到人们的重视。
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| 收稿时间： | 2013-01-09 |
Recent progress on Wnt pathway and osteosarcoma |
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| WEI Tianli,QU Guofan.Recent progress on Wnt pathway and osteosarcoma[J].Journal of Practical Oncology,2013,27(4):363-366. |
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| Authors: | WEI Tianli QU Guofan |
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| Affiliation: | Department of Orthopedics, The Affiliated Tumor Hospital of Harbin Medical University, Harbin 150081, China |
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| Abstract: | Osteosarcoma is the most prevalent primary malignant bone tumor in children and teenagers with a poor survival in 40% of the victims.The Wnt/β-catenin signaling pathway has been shown to play a major role in bone cell differentiation, proliferation and apoptosis.It is a critical component of bone mass regulation and required for bone to respond to mechanical loading.The pathway is tightly regulated by a number of modulator proteins.Mutations in pathway components that result in aberrant regulation are involved in a number of bone diseases, especially Osteosarcoma.The use of Wnt pathway associated markers appear promising for osteosarcoma.Drugs targeting the Wnt pathway will gain even more attention. |
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