| 胰腺导管腺癌免疫治疗研究现状和展望 |
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| 引用本文： | 巩芮宁,任贺.胰腺导管腺癌免疫治疗研究现状和展望[J].实用肿瘤学杂志,2022,36(6):502-506. |
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| 作者姓名： | 巩芮宁 任贺 |
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| 作者单位： | 青岛大学附属医院消化内科;消化道肿瘤诊断和治疗中心;肿瘤免疫和细胞治疗中心;医学研究中心(青岛 266003) |
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| 基金项目： | 国家杰出青年科学基金(编号:82125026);“泰山学者”人才专项(编号:Ts20190987);山东省自然科学基金重大基础研究项目(编号:ZR2020ZD11) |
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| 摘 要： | 胰腺导管腺癌(Pancreatic ductal adenocarcinoma,PDAC)是胰腺癌最常见的类型,预后极差。手术切除是目前唯一的根治手段,但多数患者就诊时已失去手术机会。免疫治疗作为一种新兴的治疗手段,在多种实体瘤和血液系统恶性肿瘤治疗中显现出乐观前景。然而,PDAC肿瘤抗原性低以及免疫抑制微环境等特征导致其免疫治疗困难重重。本文通过综述PDAC的肿瘤微环境组成特点和目前开展的新型免疫治疗策略,为PDAC的免疫治疗研究提供新思路。
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| 关 键 词： | 胰腺导管腺癌 免疫微环境 免疫治疗 免疫逃逸 |
| 收稿时间： | 2022-01-10 |
Research progress and prospect of immunotherapy for pancreatic ductal adenocarcinoma |
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| GONG Ruining,REN He.Research progress and prospect of immunotherapy for pancreatic ductal adenocarcinoma[J].Journal of Practical Oncology,2022,36(6):502-506. |
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| Authors: | GONG Ruining REN He |
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| Affiliation: | Department of Gastroenterology,The Affiliated Hospital of Qingdao University;Center for Gastrointestinal Cancer Diagnosis and Treatment;Tumor Immunology and Cytotherapy;Medical Research Center,Qingdao 266003,China |
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| Abstract: | Pancreatic ductal adenocarcinoma(PDAC)is the most common type of pancreatic cancer,and the prognosis is extremely poor.Surgical resection is the only radical cure at present,but most patients have lost the chance of surgery when they seek medical adviee.As an emerging treatment,immunotherapy shows promising prospects in the treatment of various solid tumors and hematological malignancies.However,the low antigenicity and the immunosuppressive microenvironment of PDAC make its immunotherapy difficult.This article provides new ideas for the immunotherapy research of PDAC by reviewing the characteristics of the tumor microenvironment composition of PDAC and the current novel immunotherapy strategies. |
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| Keywords: | Pancreatic ductal adenocarcinoma Immune microenvironment Immunotherapy Immune evasion |
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