| 非酒精性脂肪性肝病与消化道肿瘤的相关研究进展 |
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| 引用本文： | 王洁,曹亚萍,刘娟,祁莹,吕欢欢,时永全.非酒精性脂肪性肝病与消化道肿瘤的相关研究进展[J].现代肿瘤医学,2021,0(1):149-154. |
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| 作者姓名： | 王洁 曹亚萍 刘娟 祁莹 吕欢欢 时永全 |
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| 作者单位： | 1.西安医学院，陕西 西安 710021;2.空军军医大学西京医院消化内科，陕西 西安 710032 |
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| 基金项目： | 国家自然科学基金项目(编号:81873554);陕西省科技创新团队项目(编号:2018TD-003)。 |
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| 摘 要： | 非酒精性脂肪性肝病（NAFLD）是代谢综合征的肝脏表现，易合并心脑血管疾病、内分泌疾病、慢性肾脏病、阻塞性睡眠呼吸暂停综合征、骨质疏松症等肝外疾病，近年来众多研究发现NAFLD患者多种肝外恶性肿瘤患病率增高，并以消化道肿瘤患病率最高，本文就NAFLD与消化道肿瘤的相关研究进展及其可能的分子机制进行综述。
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| 关 键 词： | 非酒精性脂肪性肝病 食管癌 胃癌 结直肠癌 胰岛素抵抗 脂肪因子 肠道微生态 |
Research progress of non-alcoholic fatty liver disease and gastrointestinal tumors |
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| WANG Jie,CAO Yaping,LIU Juan,QI Ying,LYU Huanhuan,SHI Yongquan.Research progress of non-alcoholic fatty liver disease and gastrointestinal tumors[J].Journal of Modern Oncology,2021,0(1):149-154. |
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| Authors: | WANG Jie CAO Yaping LIU Juan QI Ying LYU Huanhuan SHI Yongquan |
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| Affiliation: | 1.Xi'an Medical University，Shaanxi Xi'an 710021，China；2.Department of Gastroenterology，Xijing Hospital，Air Force Military Medical University，Shaanxi Xi'an 710032，China. |
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| Abstract: | Non-alcoholic fatty liver disease(NAFLD)is the liver manifestation of metabolic syndrome,which is easy to be combined with cardio-cerebrovascular disease,endocrine disease,chronic kidney disease,obstructive sleep apnea syndrome,osteoporosis and other extrahepatic diseases.In recent years,many studies have found that the prevalence of multiple extrahepatic malignant tumors in NAFLD patients increased,with the highest incidence of gastrointestinal tumors.This article reviews the progress of the studies on the correlation between NAFLD and gastrointestinal tumors and the underlying molecular mechanisms of tumorigenesis. |
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| Keywords: | non-alcoholic fatty liver disease esophageal cancer gastric cancer colorectal cancer insulin resistance adipokines gut microbiota |
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