| 外泌体在肿瘤细胞与TAMs之间相互作用中“桥梁”和调控作用的研究进展 |
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| 引用本文： | 马 琳,王金格,' target='_blank'>,汪 桐,吴佳明,王 鹏,贾 晨,黄晶晶,潘华洋.外泌体在肿瘤细胞与TAMs之间相互作用中“桥梁”和调控作用的研究进展[J].现代肿瘤医学,2022,0(13):2456-2460. |
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| 作者姓名： | 马 琳 王金格 ' target='_blank'> 汪 桐 吴佳明 王 鹏 贾 晨 黄晶晶 潘华洋 |
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| 作者单位： | 1.哈尔滨医科大学口腔医学院；2.护理学院，黑龙江 哈尔滨 150086;
3.哈尔滨医科大学附属第二医院护理学教研室，黑龙江 哈尔滨 150086;
4.哈尔滨医科大学附属第一医院普外科，黑龙江 哈尔滨 150001 |
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| 基金项目： | 湖北陈孝平科技发展基金会2021年度肿瘤防治研究槐耳专项基金（编号:CXPJJH121001-2021029）；黑龙江省博士后科研启动基金（编号:LBH-Q18089）；国家大学生创新创业训练计划项目（编号:202010226016）；黑龙江省普通本科高等学校青年创新人才培养计划项目（编号:UNPYSCT-2018070) |
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| 摘 要： | 外泌体是一类直径为30~100 nm的圆盘囊泡,其内包含许多组分,诸如复杂RNA和蛋白质等,主要参与细胞间的信号转导。肿瘤相关巨噬细胞(tumor-associated macrophages,TAMs)是肿瘤微环境中普遍存在的巨噬细胞,通过对肿瘤生长、免疫逃逸、侵袭和转移、耐药性等多方面的作用影响肿瘤进程。外泌体在肿瘤相关巨噬细胞的招募、极化及抗肿瘤免疫调控等方面发挥着重要的调节功能。同时,TAMs以外泌体为媒介作用于肿瘤细胞,从而构成了外泌体、TAMs与肿瘤细胞之间相互作用的调控通路。综上所述,本文旨在阐明肿瘤细胞与TAMs之间,以外泌体为“桥梁”相互影响的潜在机制,以及靶向肿瘤细胞和TAMs来源的外泌体在恶性肿瘤治疗中的展望。
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| 关 键 词： | 外泌体 肿瘤细胞 肿瘤相关巨噬细胞 极化 治疗 |
Advances in the "bridge" and regulatory roles of exosomes in the interactions between tumor cells and TAMs |
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| MA Lin,WANG Jinge,' target='_blank'>,WANG Tong,WU Jiaming,WANG Peng,JIA Chen,HUANG Jingjing,PAN Huayang.Advances in the "bridge" and regulatory roles of exosomes in the interactions between tumor cells and TAMs[J].Journal of Modern Oncology,2022,0(13):2456-2460. |
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| Authors: | MA Lin WANG Jinge ' target='_blank'> WANG Tong WU Jiaming WANG Peng JIA Chen HUANG Jingjing PAN Huayang |
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| Affiliation: | 1.School of Stomatology;2.School of Nursing,Harbin Medical University,Heilongjiang Harbin 150086,China;3.Department of Nursing,the Second Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150086,China;4.Department of General Surgery,the First Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150001,China. |
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| Abstract: | Exosomes are a type of disc vesicles with a diameter of 30~100 nm,which contain many components,such as complex RNA and proteins,which are mainly involved in signal transduction between cells.Tumor-associated macrophages(TAMs) are ubiquitous macrophages in the tumor microenvironment.They affect tumor progression through multiple effects on tumor growth,immune escape,invasion and metastasis,and drug resistance.Exosomes play important regulatory functions in tumor-associated macrophage recruitment,polarization and anti-tumor immune regulation.At the same time,TAMs exosomes act as mediators on tumor cells,thus constituting a regulatory pathway for the interaction between exosomes,TAMs and tumor cells.To sum up,this article aims to clarify that exosomes act as a "bridge" between tumor cells and TAMs to influence each other,and the prospect of targeting tumor cells-derived and TAMs-derived exosomes in the treatment of malignant tumors. |
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| Keywords: | exosomes tumor cells tumor-associated macrophages polarization therapy |
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