| PI3K信号通路在急性髓细胞白血病治疗及耐药性调节中作用的研究进展 |
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| 引用本文： | 史永久,李 泽,李玉中.PI3K信号通路在急性髓细胞白血病治疗及耐药性调节中作用的研究进展[J].现代肿瘤医学,2022,0(16):3052-3057. |
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| 作者姓名： | 史永久 李 泽 李玉中 |
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| 作者单位： | 1.大连医科大学附属第二医院检验科，辽宁 大连 116000；2.大连医科大学，辽宁 大连 116000 |
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| 摘 要： | PI3K-AKT-mTOR通路是人体内重要的信号通路之一，其在控制细胞生长、分化、凋亡和自噬等方面都发挥着重要作用。近年来研究发现，PI3K-AKT-mTOR信号通路与急性髓系白血病（acute myeloid leukemia，AML）的发生发展密切相关。以PI3K-AKT-mTOR 通路为靶点的AML治疗也取得了很大进步。本文就PI3K-AKT-mTOR信号通路的组成、表达、调控以及该信号通路相关抑制剂在AML中的研究进展进行综述，并对今后的研究方向进行展望。
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| 关 键 词： | 急性髓系白血病 靶向治疗 PI3K-AKT-mTOR 抑制剂 |
Research on PI3K signaling pathway in the treatment of acute myeloid leukemia and the regulation of drug resistance |
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| SHI Yongjiu,LI Ze,LI Yuzhong.Research on PI3K signaling pathway in the treatment of acute myeloid leukemia and the regulation of drug resistance[J].Journal of Modern Oncology,2022,0(16):3052-3057. |
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| Authors: | SHI Yongjiu LI Ze LI Yuzhong |
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| Affiliation: | 1.Department of Clinical Laboratory,Second Affiliated Hospital of Dalian Medical University,Liaoning Dalian 116000，China;2.Dalian Medical University,Liaoning Dalian 116000，China. |
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| Abstract: | The PI3K-AKT-mTOR pathway is one of the important signaling pathways in the human body,and it plays an important role in controlling cell growth,differentiation,apoptosis,and autophagy.In recent years,studies have found that PI3K-AKT-mTOR signaling pathway is closely related to the occurrence and development of AML.Great progress has also been made in the treatment of AML targeting the PI3K-AKT-mTOR pathway.This article reviews the composition,expression and regulation of PI3K-AKT-mTOR signaling pathway and the research progress of inhibitors of this signaling pathway in AML,and prospects for future research directions. |
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| Keywords: | acute myeloid leukemia targeted therapy PI3K-AKT-mTOR inhibitor |
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