| MDM2 T309G基因多态性与前列腺癌的相关性 |
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| 引用本文： | 慕玉东,郝妮娜,原 荣,张 涛,贺 林.MDM2 T309G基因多态性与前列腺癌的相关性[J].现代肿瘤医学,2020,0(4):614-616. |
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| 作者姓名： | 慕玉东 郝妮娜 原 荣 张 涛 贺 林 |
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| 作者单位： | 1.陕西省肿瘤医院，陕西 西安 710061;
2.西安市中心医院，陕西 西安 710003 |
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| 基金项目： | 西安市科技计划项目［编号:2017114SF/YX008(11)］；陕西省卫生健康科研基金项目（编号:2018D031） |
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| 摘 要： | 目的:探讨鼠双微体基因2(MDM2) T309G基因多态性与前列腺癌相关性。方法:用酚氯法提取全基因组DNA，应用聚合酶链反应、限制性内切酶的方法检测100例前列腺癌患者和100例健康男性的MDM2 T309G基因多态性。结果:病例组中G、T等位基因型频率分别为52.5%、47.5%，对照组中G、T等位基因型频率分别为40.5%、59.5%，MDM2 T309G基因型在两组的分布有显著性差异，TT基因型在对照组分布频率明显增高（P＜0.05）。结论:MDM2 T309G基因型在病例组和对照组的分布存在明显差异，G等位基因与前列腺癌发病增加相关。
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| 关 键 词： | MDM2 单核苷酸多态性 前列腺癌 |
The correlation of gene polymorphism of MDM2 T309G and prostate cancer |
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| Mu Yudong,Hao Nina,Yuan Rong,Zhang Tao,He Lin.The correlation of gene polymorphism of MDM2 T309G and prostate cancer[J].Journal of Modern Oncology,2020,0(4):614-616. |
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| Authors: | Mu Yudong Hao Nina Yuan Rong Zhang Tao He Lin |
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| Affiliation: | 1.Shaanxi Provincial Cancer Hospital，Shaanxi Xi'an 710061,China；2.Xi'an Central Hospital，Shaanxi Xi'an 710003,China. |
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| Abstract: | Objective:To study the correlation of the single nucleotide polymorphism of MDM2 T309G and prostate cancer．Methods:The DNA was extracted by Phenol chloride.MDM2 T309G was examined by ploymerase chain reaction and restriction fragment length polymorphism in 100 cases of prostate cancer patients and 100 healthy people.Results:The frequency of G and T allele in the case group was 52.5% and 47.5%, in the control group was 40.5% and 59.5%. The distribution of MDM2 T309G genotype had significant differences in the two groups.The distribution of TT genotype in the case group was significantly lower in the control group（P＜0.05）.Conclusion:The distribution of MDM2 T309G genotype had significant differences in the two groups.G allele was associated with significantly increased risk for prostate cancer. |
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| Keywords: | MDM2 single nucleotide polymorphism prostate cancer |
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