| sema3c在胰腺癌组织中的表达及其临床意义 |
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| 引用本文： | 汤 杰,胥 明,李 琴.sema3c在胰腺癌组织中的表达及其临床意义[J].现代肿瘤医学,2021,0(12):2095-2098. |
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| 作者姓名： | 汤 杰 胥 明 李 琴 |
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| 作者单位： | 上海东方医院消化内科，上海 200120 |
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| 基金项目： | 上海市浦东新区卫生系统学科带头人培养实施计划（编号:PWRd2015-10）；上海市浦东新区卫健委三年行动计划高峰学科建设计划（编号:PWYgf2018-04) |
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| 摘 要： | 目的:探讨sema3c在胰腺癌组织中的表达及其临床意义。方法:采用免疫组织化学法对122例胰腺癌组织及癌旁组织进行sema3c表达的检测，分析sema3c表达与胰腺癌患者临床病理特征和预后的关系。结果:在122例胰腺癌组织中，共有86例表现出阳性表达，阳性率为70.5%（86/122）；在癌旁组织中共有18例表现出阳性表达，阳性率为14.8%（18/122）；两者比较有显著性差异（P=0.000）。sema3c表达与胰腺癌患者TNM分期和有无淋巴结转移有关（均P＜0.05），而与患者性别、年龄、肿瘤大小及肿瘤分化程度无关（均P＞0.05）。随访122例胰腺癌患者，sema3c阴性表达患者中位生存期为27（9,45）个月，sema3c阳性表达患者中位生存期为10（7,31）个月。sema3c阳性表达患者5年生存率明显低于sema3c阴性表达患者（P=0.011）。将122例胰腺癌患者临床病理指标纳入单因素COX回归分析，结果显示，肿瘤TNM分期、分化程度、有无淋巴结转移及sema3c表达与预后相关（均P＜0.05）。将上述影响预后的因素纳入多因素回归分析，结果显示，肿瘤TNM分期、分化程度、有无淋巴结转移及sema3c表达可作为胰腺癌患者总生存率的独立预后预测因子（均P＜0.05）。结论:sema3c可能作为胰腺癌治疗的靶点之一，对于预后判断可能具有明显价值。
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| 关 键 词： | sema3c 胰腺癌 免疫组化 预后 |
Expression of sema3c in pancreatic cancer tissues and its clinical significance |
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| TANG Jie,XU Ming,LI Qin.Expression of sema3c in pancreatic cancer tissues and its clinical significance[J].Journal of Modern Oncology,2021,0(12):2095-2098. |
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| Authors: | TANG Jie XU Ming LI Qin |
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| Affiliation: | Department of Gastroenterology,Shanghai Dongfang Hospital,Shanghai 200120,China. |
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| Abstract: | Objective:To study the expression of sema3c in pancreatic cancer tissues and its clinical significance.Methods:Immunohistochemical method was used to detect the expression of sema3c in 122 cases of pancreatic cancer tissues and adjacent tissues,and the relationship between sema3c expression and clinicopathological characteristics and prognosis of patients with pancreatic cancer was analyzed.Results:Among 122 pancreatic cancer tissues,86 cases showed positive expression,and the positive rate was 70.5% (86/122).A total of 18 cases were positive in the adjacent tissues,and the positive rate was 14.8% (18/122).There was significant difference between the two groups (P=0.000).The expression of sema3c was related to the TNM stage and the presence or absence of lymph node metastasis of pancreatic cancer (all P＜0.05).It was not related to the patient's gender,age,tumor size,and degree of tumor differentiation (all P＞0.05).Follow-up was performed on 122 patients with pancreatic cancer.The median survival of patients with sema3c negative expression was 27(9,45) months,and the median survival of patients with sema3c positive expression was 10(7,31) months.The five-year survival rate of patients with sema3c positive expression was significantly lower than that of patients with sema3c negative expression (P=0.011).The clinical and pathological parameters of 122 patients with pancreatic cancer were included in univariate COX regression analysis.The results showed that tumor TNM stage,degree of differentiation,the presence or absence of lymph node metastasis and sema3c expression were correlated with prognosis (all P＜0.05).The above factors affecting prognosis were included in multivariate regression analysis.The results showed that tumor TNM stage,degree of differentiation,the presence or absence of lymph node metastasis and sema3c expression can be used as independent prognostic factors for overall survival of patients with pancreatic cancer (all P＜0.05).Conclusion:sema3c may be one of the targets for the treatment of pancreatic cancer,and it may have obvious value for judging the prognosis. |
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| Keywords: | sema3c pancreatic cancer immunohistochemistry prognosis |
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