| 血清IL-17A与干扰素γ诱导蛋白10在原发性肝癌中的表达及临床意义 |
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| 引用本文： | 李 玮,谢友利,刘雅娟,吴兰梅.血清IL-17A与干扰素γ诱导蛋白10在原发性肝癌中的表达及临床意义[J].现代肿瘤医学,2021,0(18):3228-3232. |
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| 作者姓名： | 李 玮 谢友利 刘雅娟 吴兰梅 |
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| 作者单位： | 武汉大学中南医院肝胆胰腺外科，湖北 武汉 430071 |
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| 摘 要： | 目的:探讨血清IL-17A与干扰素γ诱导蛋白10（IP-10）在原发性肝癌中的表达及临床意义。方法:收集2015年1月至2017年12月我科收治的原发性肝癌患者182例（实验组）及健康体检者50例（对照组），检测两组受试者血清IL-17A、IP-10值，比较两组血清IL-17A、IP-10水平差异，分析血清IL-17A、IP-10对原发性肝癌早期诊断的预测价值。结果:实验组患者术前血清IL-17A、IP-10水平分别高于对照组血清IL-17A、IP-10水平（P＜0.05）；实验组患者术后血清IL-17A、IP-10水平分别低于实验组患者术前血清IL-17A、IP-10水平（P＜0.05）；原发性肝癌患者不同病理组织分型间血清IL-17A、IP-10水平相比，差异具有统计学意义（P＜0.05）；原发性肝癌Ⅲ期患者的血清IL-17A、IP-10水平分别高于原发性肝癌Ⅰ、Ⅱ期患者的血清IL-17A、IP-10水平（P＜0.05）。多因素分析结果示:血清TBil、AST、ALT、AFP、IL-17A、IP-10水平升高是原发性肝癌发生的独立危险因素。ROC曲线示:血清IL-17A曲线下面积为0.793，敏感度和特异度分别为0.827和0.619；IP-10曲线下面积为0.757，敏感度和特异度分别为0.796和0.714；血清IL-17A、IP-10联合检测曲线下面积为0.883，敏感度和特异度分别为0.898和0.810。结论:血清IL-17A、IP-10水平升高在原发性肝癌病情进展中起重要作用，可作为原发性肝癌早期诊断预测指标之一。
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| 关 键 词： | 白细胞介素-17A 干扰素γ诱导蛋白10 肝癌 |
Expression of serum IL-17A and interferon gamma-inducible protein 10 in primary liver cancer and its clinical significance |
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| LI Wei,XIE Youli,LIU Yajuan,WU Lanmei.Expression of serum IL-17A and interferon gamma-inducible protein 10 in primary liver cancer and its clinical significance[J].Journal of Modern Oncology,2021,0(18):3228-3232. |
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| Authors: | LI Wei XIE Youli LIU Yajuan WU Lanmei |
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| Affiliation: | Hepatobiliary and Pancreatic Surgery，Central South Hospital of Wuhan University，Hubei Wuhan 430071，China. |
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| Abstract: | Objective:To investigate the expression and clinical significance of serum IL-17A and interferon gamma-inducible protein 10 (IP-10) in primary liver cancer.Methods:A total of 182 patients with primary liver cancer (experimental group) and 50 healthy subjects (control group) were enrolled from January 2015 to December 2017.The serum levels of IL-17A and IP-10 were detected in the two groups.The difference of serum IL-17A and IP-10 levels between the two groups was compared,and the predictive value of serum IL-17A and IP-10 for early diagnosis of primary liver cancer was analyzed.Results:The preoperative levels of serum IL-17A,IP-10 in the experimental group was higher than that of serum IL-17A and IP-10 in the control group (P＜0.05).The postoperative levels of serum IL-17A and IP-10 in the experimental group were lower than those preoperative levels of serum IL-17A and IP-10 in the experimental group (P＜0.05).There were significant differences in serum IL-17A and IP-10 levels between different pathological tissue types of patients with primary liver cancer (P＜0.05).The levels of serum IL-17A and IP-10 in stage Ⅲ of primary liver cancer were higher than that of serum IL-17A and IP-10 in stage Ⅰ and Ⅱ of patients with primary liver cancer (P＜0.05).Multivariate analysis showed that elevated serum TBil,AST,ALT,AFP,IL-17A,and IP-10 levels were indenpendent risk factors for primary liver cancer.The ROC curve showed that the area under the serum IL-17A curve was 0.793,and the sensitivity and specificity were 0.827 and 0.619,respectively.The area under the IP-10 curve was 0.757,and the sensitivity and specificity were 0.796 and 0.714,respectively.The area under the serum IL-17A combined with IP-10 was 0.883,and the sensitivity and specificity were 0.898 and 0.810,respectively.Conclusion:The elevated levels of serum IL-17A and IP-10 play an important role in the progression of primary liver cancer,and can be used as one of the early diagnostic indicators for primary liver cancer. |
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| Keywords: | interleukin-17A interferon gamma-inducible protein 10 liver cancer |
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