| 非霍奇金淋巴瘤化疗后脂肪肝形成临床研究 |
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| 引用本文： | 张亦琳,赵万红,张王刚,何爱丽,曹星梅,刘 捷,陈银霞,王剑利,陈社平,杨 云,马肖容,古流芳,王 瑾.非霍奇金淋巴瘤化疗后脂肪肝形成临床研究[J].现代肿瘤医学,2018,0(24):4004-4007. |
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| 作者姓名： | 张亦琳 赵万红 张王刚 何爱丽 曹星梅 刘 捷 陈银霞 王剑利 陈社平 杨 云 马肖容 古流芳 王 瑾 |
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| 作者单位： | 西安交通大学医学院第二附属医院血液科，陕西 西安 710004 |
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| 摘 要： | 目的:探讨非霍奇金淋巴瘤患者化疗后脂肪肝的发生率与影响因素。方法:2014年1月至2015年12月，共收集了西安交通大学医学院第二附属医院血液科158例非霍奇金淋巴瘤患者的临床资料，对比化疗前后肝脏B超、生化指标转氨酶［肝功谷草转氨酶（aspartate transaminase，AST）、谷丙转氨酶（alanine transaminase，ALT）］及血脂［胆固醇（cholesterol， CHOL）、甘油三脂（triglyceride，TG）、低密度脂蛋白（low densith lipoprotein，LDL）、高密度脂蛋白（high density lipoprotein，HDL）］等水平的变化。结果:在158例患者中，化疗期间共有59例患者超声检查诊断为脂肪肝，发生率达37.3%，与化疗前具有显著差异；出现脂肪肝时间为化疗后1.5~17.0个月，平均5.4个月；化疗2.0~12.0个疗程出现，平均4.2个疗程。出现脂肪肝患者从初诊到诊断脂肪肝时体重增长-7.1~23.2 kg，平均增长5.5 kg。不同性别、年龄、淋巴瘤类型之间，脂肪肝发生率差异不具有统计学意义。化疗后患者肝功转氨酶及血脂水平均有不同程度升高，差异具有统计学意义，11例合并脂肪肝患者在化疗完全结束后3~9个月B超检测肝脏恢复正常，无脂肪肝表现。结论:非霍奇金淋巴瘤患者化疗后可发生肝功损害、血脂异常，部分可发展为脂肪肝，临床医师应认识到脂肪肝危害，及早发现并处理。
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| 关 键 词： | 非霍奇金淋巴瘤 化疗 脂肪肝 |
Clinical analysis of fatty liver caused by non-Hodgkin lymphoma chemotherapy |
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| Zhang Yilin,Zhao Wanhong,Zhang Wanggang,He Aili,Cao Xingmei,Liu Jie,Chen Yinxia,Wang Jianli,Chen Sheping,Yang Yun,Ma Xiaorong,Gu Liufang,Wang Jin.Clinical analysis of fatty liver caused by non-Hodgkin lymphoma chemotherapy[J].Journal of Modern Oncology,2018,0(24):4004-4007. |
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| Authors: | Zhang Yilin Zhao Wanhong Zhang Wanggang He Aili Cao Xingmei Liu Jie Chen Yinxia Wang Jianli Chen Sheping Yang Yun Ma Xiaorong Gu Liufang Wang Jin |
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| Affiliation: | Department of Hematology,the Second Affiliated Hospital of Medical College of Xi'an Jiaotong University,Shaanxi Xi'an 710004,China. |
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| Abstract: | Objective:To investigate the incidence and risk factors of fatty liver caused by non-Hodgkin lymphoma chemotherapy.Methods:From January 2014 to December 2015,our department carried out clinical researches on 158 patients with non-Hodgkin lymphoma,analyze the changes of liver ultrasound and laboratory biochemical indicators［ALT(alanine transaminase),AST(aspartate transaminase),CHOL(cholesterol),TG(triglyceride),HDL(high density lipoprotein),LDL(low densith lipoprotein)］ before and after chemotherapy.Results:59 of 158 patients showed fatty liver after chemotherapy,the incidence was 37.3%.The occurrences of fatty liver were 1.5 to 17.0 months after chemotherapy,the average of which was 5.4 months,and it occurred after 2.0 to 12.0 chemotherapy courses with the average of 4.2.In the patients with fatty liver,the weight was increased -7.1 to 23.2 kg with the average of 5.5 kg from initial to the diagnosis of fatty liver.There was no significant difference in the incidence of fatty liver between different genders,ages and lymphoma types.The laboratory biochemical indicators had varying degrees of raises and showed significant difference before and after chemotherapy.The livers of 11 fatty liver patients recovered normal in 3 to 9 months after all the chemotherapy completed.Conclusion:The patients of non-Hodgkin lymphoma can develop hepatic dysfunction and dyslipidemia after chemotherapy,and can cause the fatty liver.As clinicians,we should recognize the risk of fatty liver and deal with it earlier. |
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| Keywords: | non-Hodgkin lymphoma chemotherapy fatty liver |
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