| 结肠癌患者血清fibulin-3水平与临床病理特征的关系 |
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| 引用本文： | 杨 洋,陆 雄,李 华,马 蓉.结肠癌患者血清fibulin-3水平与临床病理特征的关系[J].现代肿瘤医学,2018,0(19):3087-3090. |
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| 作者姓名： | 杨 洋 陆 雄 李 华 马 蓉 |
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| 作者单位： | 1.宝鸡市人民医院普外科，陕西 宝鸡 721000;2.西安交通大学医学院第二附属医院普外科，陕西 西安 710004 |
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| 基金项目： | 陕西省自然科学基础研究计划项目(编号:2012JQ4016);西安交通大学基本科研业务费（编号:Xjj2012072） |
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| 摘 要： | 目的:比较结肠癌患者与健康对照者血清fibulin-3水平，研究血清fibulin-3水平与患者临床病理特征之间的关系。方法:选取2013年10月至2015年6月我院收治的80例结肠癌患者［平均年龄(58.99±5.47)岁，男性42例］以及50例健康体检者［平均年龄(57.75±6.01)岁，男性27例］作为研究对象。使用ELISA法（酶联免疫吸附法）对患者血清fibulin-3水平进行检测。结果:术前结肠癌患者的血清fibulin-3水平（35.91±27.14）ng/ml显著低于对照组（96.61±45.52）ng/ml（P<0.001）。血清fibulin-3水平随患者的肿瘤程度（淋巴血管侵袭、远处转移、淋巴结转移和TNM分期）减轻明显降低（P<0.001），从T1到T4期肿瘤fibulin-3血清水平显著减少（P<0.001）。血清fibulin-3水平和肿瘤的大小、T分期、远处转移、淋巴结转移和淋巴血管侵袭显著相关（P<0.01）。结论:fibulin-3在结肠癌患者中的表达水平显著低于健康者，且与结肠癌的肿瘤程度显著相关，fibulin-3的下降可作为晚期结肠癌的标记。
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| 关 键 词： | fibulin-3 结肠癌 临床分期 |
Study on the relationship between plasma fibulin-3 level and clinical pathological features in patients with colon cancer |
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| Yang Yang,Lu Xiong,Li Hua,Ma Rong.Study on the relationship between plasma fibulin-3 level and clinical pathological features in patients with colon cancer[J].Journal of Modern Oncology,2018,0(19):3087-3090. |
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| Authors: | Yang Yang Lu Xiong Li Hua Ma Rong |
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| Affiliation: | 1.Department of General Surgery，Baoji People's Hospital，Shaanxi Baoji 721000，China；2.Department of General Surgery，the Second
Affiliated Hospital，Medical School of Xi'an Jiaotong University，Shaanxi Xi'an 710004，China;3.Department of Pathology，Baoji People's Hospital，Shaanxi Baoji 721000，China. |
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| Abstract: | Objective:To assess serum fibulin-3 levels in patients with colon cancer compared with healthy controls and its relationship to demographics and tumor pathology.Methods:A total of 80 patients ［mean age，(58.99±5.47)years,42 males］ with colon cancer and 50 controls ［mean age，(57.75±6.01)years,27 males］ in our hospital from October 2013 to June 2015 were included.Serum levels of fibulin-3 were determined using a commercially available sandwich ELISA.Results:Preoperative serum fibulin-3 levels were significantly lower in the group of patients with colon cancer ［(35.91±27.14)ng/ml,range，10~73 ng/ml］ compared with the control group ［(96.61±45.52)ng/ml,range，57~168 ng/ml］ (P<0.001).The serum fibulin-3 levels were significantly lower in patients with colon cancer with reducing tumor burden，lymph vascular involvement，distant metastasis，lymph node metastasis，and TNM stages (P<0.001).The serum fibulin-3 levels were correlated significantly with tumor size，distant metastasis，lymph node metastasis，and lymph vascular involvement (P<0.01).Conclusion:It was concluded that fibulin-3 is expressed at a lower level in patients with colon cancer when compared with healthy people，and the fibulin-3 level it is significant correlated with tumor burden，decreased level of fibulin-3 can serve as a marker for advanced colon cancer. |
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| Keywords: | fibulin-3 colon cancer clinical stage |
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