| 海南人咀嚼槟榔引起的口腔鳞状细胞癌ceRNA网络分析 |
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| 引用本文： | 朱乔,邵小钧,甯超学,赵亚力.海南人咀嚼槟榔引起的口腔鳞状细胞癌ceRNA网络分析[J].现代肿瘤医学,2021,0(4):573-579. |
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| 作者姓名： | 朱乔 邵小钧 甯超学 赵亚力 |
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| 作者单位： | 1.解放军总医院海南医院中心实验室；2.口腔科，海南 三亚 572000 |
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| 基金项目： | 三亚市医疗卫生科技创新项目(编号:2017YW23)。 |
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| 摘 要： | 目的:构建咀嚼槟榔引起的口腔鳞状细胞癌（OSCC）的ceRNA网络，探究其表达异常可能影响的调节通路改变。方法:对咀嚼槟榔的OSCC及癌旁组织进行miRNA测序和lncRNA微阵列分析，并建立了ceRNA网络。结果:lncRNA-miRNA-mRNA网络由308个lncRNA，41个miRNA和115个mRNA组成。结论:GO和KEGG分析表明，ceRNA网络参与了MAPK、凋亡、p53和PI3K/Akt等不同的信号通路。
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| 关 键 词： | 槟榔 口腔鳞状细胞癌 ceRNA 海南 |
Identifcation of miRNA,lncRNA and mRNA-associated ceRNA networks and potential biomarker for oral squamous cell carcinoma with betel quid chewing in Hainan |
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| ZHU Qiao,SHAO Xiaojun,NING Chaoxue,ZHAO Yali.Identifcation of miRNA,lncRNA and mRNA-associated ceRNA networks and potential biomarker for oral squamous cell carcinoma with betel quid chewing in Hainan[J].Journal of Modern Oncology,2021,0(4):573-579. |
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| Authors: | ZHU Qiao SHAO Xiaojun NING Chaoxue ZHAO Yali |
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| Affiliation: | 1.Central Laboratory；2.Stomatology Department,Hainan Hospital of PLA General Hospital,Hainan Sanya 572000,China. |
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| Abstract: | Objective:To construct the ceRNA network of oral squamous cell carcinoma(OSCC)induced by betel quid(BQ),and to explore the changes of regulatory pathways that may be affected by abnormal expression ceRNA.Methods:OSCC patients with BQ chewing were involved in this study and participants acted as their own control.MicroRNA sequencing and lncRNA microarray analysis were done.Subsequently,we established the ceRNA network.Results:ceRNA network was conducted in OSCC with BQ chewing.The lncRNA-miRNA-mRNA network was formed by 308 lncRNAs,41 miRNAs and 115 mRNAs.Conclusion:GO and KEGG analysis showed that the network involved in different signal pathways,such as the MAPK,apoptosis,p53 and PI3K/Akt signaling pathway. |
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| Keywords: | betel quid OSCC ceRNA Hainan |
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