| 结直肠癌患者术前焦虑状态与细胞因子水平变化关系的研究 |
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| 引用本文： | 张 婵,孙光为,陈美旭,张慧杰,董晓梅,刘 盈.结直肠癌患者术前焦虑状态与细胞因子水平变化关系的研究[J].现代肿瘤医学,2019,0(11):1931-1936. |
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| 作者姓名： | 张 婵 孙光为 陈美旭 张慧杰 董晓梅 刘 盈 |
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| 作者单位： | 1.中国医科大学附属第一医院精神医学科；2.肛肠外科，辽宁 沈阳 110001;3.沈阳师范大学教育科学学院应用心理学教研室，辽宁 沈阳 110034 |
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| 基金项目： | National Natural Science Foundation of China（No.81472853）;国家自然科学基金项目（编号:81472853） |
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| 摘 要： | 目的:探究结直肠癌（colorectal cancer，CRC）患者术前焦虑状态与血浆细胞因子水平变化的关系。方法:选取结直肠癌患者93名，采用汉密尔顿焦虑量表（Hamilton Rating Scale for Anxiety，HAMA）、纽芬兰纪念大学主观幸福感量表（Memorial University of Newfoundland Scale of Happiness，MUNSH）、癌症患者生命质量测定量表（Quality of Life Questionnaire，QLQ-C30）、自尊量表（self-esteem scale，SES）评估患者身心健康状况，根据HAMA评分将CRC患者分为三组:HAMA<7（无焦虑组）42人，7≤HAMA＜14(可能焦虑组)30人，HAMA≥14(焦虑组)21人。用LUMINEX（悬液芯片技术）检测各组血浆G-CSF、GM-CSF、IL-2、IL-6、IL-8、IL-10、IL-12p70、IL-13、IL-17A、IL-1β、MCP-1、TNF-α、IFN-γ水平。结果:无焦虑组和可能焦虑组、焦虑组的MUNSH、SES、QLQ-C30总分的差异均有统计学意义（P<0.05），可能焦虑组和焦虑组MUNSH、SES、QLQ-C30总分的差异无统计学意义（P>0.05）。三组CRC患者的G-CSF、GM-CSF、IL-2、IL-6、IL-8、IL-10、IL-12p70、IL-1β、MCP-1、TNF-α、IFN-γ随HAMA分值的增高存在相似的倒“V”型变化趋势:细胞因子在HAMA＜7组水平最低，在7≤HAMA＜14组水平最高，在HAMA＞14组较前者出现下降，但仍高于HAMA＜7组（IL-1β除外）。G-CSF（P=0.017、IL-10(P=0.035)、IL-12p70(P=0.047)、IFN-γ(P=0.029)在三组之间的差异有统计学意义。结论:不同焦虑程度的结直肠癌患者外周血中的细胞因子水平有所不同，可能焦虑组的结直肠癌患者同样需要临床和科研工作者的重视。
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| 关 键 词： | 结直肠癌 焦虑状态 细胞因子 |
The relationship between anxiety and preoperative inflammatory cytokines in patients with colorectal cancer |
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| Zhang Chan,Sun Guangwei,Chen Meixu,Zhang Huijie,Dong Xiaomei,Liu Ying.The relationship between anxiety and preoperative inflammatory cytokines in patients with colorectal cancer[J].Journal of Modern Oncology,2019,0(11):1931-1936. |
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| Authors: | Zhang Chan Sun Guangwei Chen Meixu Zhang Huijie Dong Xiaomei Liu Ying |
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| Affiliation: | 1.Department of Psychiatry；2.Department of Anorectal，the First Affiliated Hospital of China Medical University，Liaoning Shenyang 110001，China；3.School of Education Science，Shenyang Normal University，Liaoning Shenyang 110034，China. |
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| Abstract: | Objective: To explore the association between anxiety and inflammatory cytokine levels in colorectal cancer (CRC) patients.Methods:Ninety-three colorectal cancer (CRC)patients were assessed by The Hamilton Rating Scale for Anxiety (HAMA)，Memorial University of Newfoundland Scale of Happiness (MUNSH)，Quality of Life Questionnaire (QLQ-C30)and self-esteem scale (SES) to measure the psychological and physical wellbeing.CRC patients were classified into three groups:HAMA<7 (non-anxiety)，7≤HAMA<14 (possible anxiety)，and HAMA≥14 (anxiety).LUMINEX was conducted to quantify the inflammatory cytokines G-CSF，GM-CSF，IL-2，IL-6，IL-8，IL-10，IL-12p70，IL-13，IL-17A，IL-1β，MCP-1，TNF-α，and IFN-γ in the plasma.Results:The total scores of MUNSH，SES，and QLQ-C30 of the non-anxiety group were significantly different from the possible anxiety group and the anxiety group (P<0.05).The total scores of MUNSH，SES，and QLQ-C30 of the possible anxiety group were not significantly different from the anxiety group (P>0.05).There was a similar inverted "V" trend in G-CSF，GM-CSF，IL-2，IL-6，IL-8，IL-10，IL-12p70，IL-1β，MCP-1，TNF-α，IFN-γ with the increase of HAMA score in CRC groups:Cytokines were the lowest in HAMA<7 group and highest in 7≤HAMA<14 group respectively，with HAMA>14 group decreased despite its higher than HAMA<7 group (except for IL-1β).The CRC groups differed statistically significant in G-CSF (P=0.017)，IL-10 (P=0.035)，IL-12p70 (P=0.047)，and IFN-γ (P=0.029).Conclusion:The levels of cytokines may be different in CRC patients with different degrees of anxiety and we may need to focus on the possible anxiety patients. |
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| Keywords: | colorectal cancer anxiety cytokines |
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