| 实体瘤化疗引起Ⅳ度骨髓抑制的临床分析 |
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| 引用本文： | 高 艳,江启安,李敬国,王文明.实体瘤化疗引起Ⅳ度骨髓抑制的临床分析[J].现代肿瘤医学,2019,0(1):111-116. |
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| 作者姓名： | 高 艳 江启安 李敬国 王文明 |
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| 作者单位： | 安徽医科大学附属安庆医院肿瘤内科，安徽 安庆 246003 |
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| 摘 要： | 目的:探讨实体瘤常规剂量化疗后出现Ⅳ度骨髓抑制的危险因素。方法:收集43例常规剂量化疗后出现Ⅳ度骨髓抑制的实体瘤患者及51例出现0-Ⅱ度骨髓抑制的实体瘤患者的临床资料，来探讨出现Ⅳ度骨髓抑制的危险因素及防治措施。结果:转移器官数目、化疗周期数、既往骨髓抑制程度是发生Ⅳ度骨髓抑制的独立危险因素（P=0.002、0.002、0.001）。在分组分析中，这三个因素也是发生Ⅳ度白细胞减少的独立危险因素（P=0.008、0.030、0.001）。结论:对于转移器官数目较多、曾行多周期化疗、既往曾发生严重骨髓抑制的患者在化疗期间予有效的预防措施及严密的随访，有利于防治Ⅳ度骨髓抑制。
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| 关 键 词： | 实体瘤 化疗 Ⅳ度骨髓抑制 危险因素 |
Related factors of grade IV myelosupression of patients with solid tumor after chemotherapy |
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| Gao Yan,Jiang Qi'an,Li Jingguo,Wang Wenming.Related factors of grade IV myelosupression of patients with solid tumor after chemotherapy[J].Journal of Modern Oncology,2019,0(1):111-116. |
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| Authors: | Gao Yan Jiang Qi'an Li Jingguo Wang Wenming |
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| Affiliation: | Department of Oncology，Anqing Hospital Affiliated to Anhui Medical University，Anhui Anqing 246003，China. |
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| Abstract: | Objective:To study the related risk factors of grade Ⅳ myelosupression of patients with solid tumor after conventional dosage chemotherapy.Methods:Collect the clinical data of 94 patients with solid tumor after conventional dosage chemotherapy，among whom，43 developed grade Ⅳ myelosupression，and 51 developed grade 0-Ⅱ myelosupression，to study the related risk factors of grade Ⅳ myelosupression and prophylactico-therapeutic measures.Results:The number of metastatic sites，the number of chemotherapy and the level of myelosupression occur in previous chemotherapy is independent risk factors of grade Ⅳ myelosupression(P=0.002，0.002，0.001 respectively).Subset analyses showed these three factors also is independent risk factors of grade Ⅳ leukocytopenia(P=0.008，0.030，0.001 respectively).Conclusion:Giving prophylactico-therapeutic measures and close follow-up to the patients who with more number of metastatic sites、more number of chemotherapy and severe level of myelosupression occur in previous chemotherapy can help prevent the happeness of grade Ⅳ myelosupression. |
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| Keywords: | solid tumor chemotherapy grade Ⅳ myelosupression risk factors |
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