| 亚甲基四氢叶酸还原酶多态性与乳腺癌化疗敏感性的相关研究 |
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| 引用本文： | 胡凤娣,杨继岚,谢 琳,李 杨,龙庭凤,沈丽达,邹天宁.亚甲基四氢叶酸还原酶多态性与乳腺癌化疗敏感性的相关研究[J].现代肿瘤医学,2019,0(4):588-591. |
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| 作者姓名： | 胡凤娣 杨继岚 谢 琳 李 杨 龙庭凤 沈丽达 邹天宁 |
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| 作者单位： | 1.云南省肿瘤医院，昆明医科大学第三附属医院内一科；2.乳腺外一科,云南 昆明 650118 |
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| 基金项目： | 云南省教育厅科学研究基金项目(编号:2014Y162)；昆明医科大学应用基础研究联合专项资金项目(编号:2014FZ035) |
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| 摘 要： | 目的:观察叶酸代谢的关键酶亚甲基四氢叶酸还原酶(MTHFR)基因C677T、A1298C多态性与乳腺癌FEC方案化疗敏感性的关系。方法:收集经病理学确诊的初治乳腺癌患者104例，所有病例化疗前抽静脉血,提取DNA,用PCR-RFLP技术检测MTHFR基因型，所有患者行FEC方案新辅助或姑息性化疗2~6周期，比较疗效和基因型之间的关系。结果:104例乳腺癌患者中,MTHFR C677T T/T基因型39例(37.5%)、C/C基因型55例(52.9%)、C/T基因型 10例(9.6%)；T/T基因型化疗有效率79.5%(31/39)高于C/C基因型52.7%(29/55)和C/T基因型20.0%(2/10)（P＜0.05）。MTHFR A1298C A/A基因型41例(39.4%),A/C基因型56例(53.8%),C/C基因型7例(6.7%)；各基因型化疗有效率之间无统计学关系（P＞0.05）。结论:本研究初步显示MTHFR C677T基因多态性对预测乳腺癌化疗效果具有较好的临床应用价值。
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| 关 键 词： | 乳腺癌 亚甲基四氢叶酸还原酶 化学治疗 基因型 |
Effects of MTHFR polymorphism on breast cancer chemotherapeutic sensitivity |
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| Hu Fengdi,Yang Jilan,Xie Lin,Li Yang,Long Tingfeng,Shen Lida,Zou Tianning.Effects of MTHFR polymorphism on breast cancer chemotherapeutic sensitivity[J].Journal of Modern Oncology,2019,0(4):588-591. |
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| Authors: | Hu Fengdi Yang Jilan Xie Lin Li Yang Long Tingfeng Shen Lida Zou Tianning |
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| Affiliation: | 1.Department of Medical Oncology；2.Department of Breast Surgery，The Third Affiliated Hospital of Kunming Medical University，Yunnan Province Tumor Hospital,Yunnan Kunming 650118,China. |
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| Abstract: | Objective:To investigate the effects of MTHFR polymorphism on breast cancer chemotherapeutic sensitivity.Methods:104 breast cancer patients confirmed by pathology were treated with FEC regimen 2~6 cycles and DNA of peripheral blood was obtained．MTHFR genotypes were detected by PCR-RFLP.Patients with different genotypes were compared with the chemotherapeutic sensitivity.Results:Of the 104 patients,the frequencies of MTHFR C677T T/T,C/C and C/T genotype were 39(37.5%),55(52.9%) and 10(9.6%) respectively.Chemotherapeutic sensitivity of patients with T/T genotype was higher than C/C genotype and C/T genotype（P＜0.05）。The frequencies of MTHFR A1298C A/A,A/C and C/C genotype were 41(39.4%),56(53.8%) and 7(6.7%) respectively.There was no statistic significance in chemotherapeutic sensitivity and genotype（P＞0.05）．Conclusion:The present study indicates that polymorphisms of MTHFR may be an important clinical value to predict the breast cancer chemotherapeutic sensitivity. |
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| Keywords: | breast cancer methylenetetrahydrofolate reductase（MTHFR） chemotherapy genotype |
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